Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Yammine, S; Singer, F; Abbas, C; Roos, M; Latzin, P.
Multiple-breath washout measurements can be significantly shortened in children.
Thorax. 2013; 68(6):586-7
Doi: 10.1136/thoraxjnl-2012-202345
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- Co-Autor*innen der Med Uni Graz
- Singer Florian
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- Abstract:
- Multiple-breath washout (MBW)-derived lung clearance index (LCI) is a sensitive measure of ventilation inhomogeneity in patients with cystic fibrosis (CF), but LCI measurement is time consuming. We systematically assessed ways to shorten LCI measurements. In 68 school-aged children (44 with mild CF lung disease) three standard nitrogen (N2) MBWs were applied. We assessed repeatability and diagnostic performance of (1) LCI measured earlier from three MBW runs and (2) LCI measured at complete MBW (1/40th of starting N2 concentration) from two runs only. Compared with the standard LCI from three complete MBW runs, the new LCI based on three N2MBW runs until 1/20th, or two complete runs until 1/40th, provided similar or better repeatability as well as sensitivity and specificity for CF lung disease. Alternative ways to measure LCI reduced test duration in children with CF by 30% and 41%, respectively. LCI measurements can be reliably shortened in children. These new MBW protocols may advance the transition of LCI from research into clinical settings.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent - administration & dosage
- Breath Tests - methods
- Child - administration & dosage
- Cystic Fibrosis - diagnosis, physiopathology
- Exhalation - administration & dosage
- Female - administration & dosage
- Forced Expiratory Volume - administration & dosage
- Humans - administration & dosage
- Lung Diseases - diagnosis, physiopathology
- Male - administration & dosage
- Nitrogen Dioxide - analysis
- ROC Curve - administration & dosage