Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Subbarao, P; Milla, C; Aurora, P; Davies, JC; Davis, SD; Hall, GL; Heltshe, S; Latzin, P; Lindblad, A; Pittman, JE; Robinson, PD; Rosenfeld, M; Singer, F; Starner, TD; Ratjen, F; Morgan, W.
Multiple-Breath Washout as a Lung Function Test in Cystic Fibrosis. A Cystic Fibrosis Foundation Workshop Report.
Ann Am Thorac Soc. 2015; 12(6):932-9
Doi: 10.1513/AnnalsATS.201501-021FR
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- Co-Autor*innen der Med Uni Graz
- Singer Florian
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- Abstract:
- The lung clearance index (LCI) is a lung function parameter derived from the multiple-breath washout (MBW) test. Although first developed 60 years ago, the technique was not widely used for many years. Recent technological advances in equipment design have produced gains in popularity for this test among cystic fibrosis (CF) researchers and clinicians, particularly for testing preschool-aged children. LCI has been shown to be feasible and sensitive to early CF lung disease in patients of all ages from infancy to adulthood. A workshop was convened in January 2014 by the North American Cystic Fibrosis Foundation to determine the readiness of the LCI for use in multicenter clinical trials as well as clinical care. The workshop concluded that the MBW text is a valuable potential outcome measure for CF clinical trials in preschool-aged patients and in older patients with FEV1 in the normal range. However, gaps in knowledge about the choice of device, gas, and standardization across systems are key issues precluding its use as a clinical trial end point in infants. Based on the current evidence, there are insufficient data to support the use of LCI or MBW parameters in the routine clinical management of patients with CF.
- Find related publications in this database (using NLM MeSH Indexing)
- Breath Tests - instrumentation, methods
- Child, Preschool - administration & dosage
- Cystic Fibrosis - diagnosis, physiopathology
- Disease Progression - administration & dosage
- Flowmeters - administration & dosage
- Forced Expiratory Volume - administration & dosage
- Humans - administration & dosage
- Infant - administration & dosage
- Infant, Newborn - administration & dosage
- Monitoring, Physiologic - methods
- Outcome Assessment, Health Care - administration & dosage
- Prognosis - administration & dosage
- Reproducibility of Results - administration & dosage
- Respiratory Function Tests - methods
- Find related publications in this database (Keywords)
- multiple-breath washout
- lung clearance index
- cystic fibrosis
- pulmonary function tests