Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Singer, F; Horak, F; Friesenbichler, W; Schneider, B; Szépfalusi, Z; Frischer, T.
Cysteinyl-leukotrienes in nasal lavage fluid in children with asthma.
Pediatr Allergy Immunol. 2008; 19(3):227-32
Doi: 10.1111/j.1399-3038.2007.00614.x
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Singer Florian
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- Abstract:
- The aim of this study was to investigate repeatability of cysteinyl-leukotrienes (cys-LT) measurements in nasal lavage fluid (NLF) and to determine if cys-LT levels in NLF are related to asthma severity in children. As a second outcome, we investigated if cys-LT in NLF reflect lower airway inflammation as assessed by exhaled NO measurement. To assess the repeatability of cys-LT measurements, two NLF samples were obtained from eight healthy controls 24 h apart. Sixty-nine asthmatic children (mean age; range: 12.8; 7.3-17.7 yr), which were grouped according to asthma severity were studied cross-sectionally on one occasion. Cys-LT in NLF were analyzed using a specific enzyme immunoassay, exhaled NO, and pulmonary function parameters were measured. The coefficient of repeatability for the repeated cys-LT measurements was 1.45 pg/ml. Cys-LT levels in NLF differed significantly between asthma severity groups (p < 0.001): mild intermittent: [median (IQR)] 6.88 pg/ml (2.00-27.87); mild persistent: 21.09 pg/ml (4.50-84.67); and moderate persistent asthmatics: 36.41 pg/ml (11.03-118.40). Concentration of cys-LT in NLF and exhaled NO was positively correlated (r = 0.85; p < 0.001). In conclusion, concentration of cys-LT in NLF correlates with asthma severity in children and is related to lower airway inflammation.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent - administration & dosage
- Asthma - diagnosis
- Breath Tests - administration & dosage
- Child - administration & dosage
- Cross-Sectional Studies - administration & dosage
- Cysteine - analysis
- Female - administration & dosage
- Humans - administration & dosage
- Leukotrienes - analysis
- Male - administration & dosage
- Nasal Lavage Fluid - chemistry
- Nitric Oxide - analysis
- Reproducibility of Results - administration & dosage
- Find related publications in this database (Keywords)
- asthma
- inflammation
- leukotriene
- exhaled nitric oxide
- nasal lavage
- children