Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Horak, F; Moeller, A; Singer, F; Straub, D; Höller, B; Helbich, TH; Schneider, B; Eichler, I; Wildhaber, JH; Hall, GL.
Longitudinal monitoring of pediatric cystic fibrosis lung disease using nitrite in exhaled breath condensate.
Pediatr Pulmonol. 2007; 42(12):1198-206
Doi: 10.1002/ppul.20719
Web of Science
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- Co-authors Med Uni Graz
- Singer Florian
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- Abstract:
- Cystic fibrosis (CF) lung disease is characterized by airway inflammation and airway infection. Nitrites in exhaled breath condensate (EBC-NO(2)(-)) have been shown to be increased in children and adults with CF compared to healthy controls suggesting its use as a measure of airway inflammation. This longitudinal study aimed to evaluate if repeated measurements of EBC-NO(2)(-) are helpful in monitoring CF lung disease activity in children. Thirty-two children with mild CF lung disease (age 10.6 +/- 3.3 years) were recruited in two study centers. Follow-up visits occurred every 3 months over a period of 1 year with a total of five visits. Each visit included a clinical assessment incorporating a modified Shwachman-Kulczycki (SK) score, spirometry, an oropharyngeal swab, or sputum sample for bacterial analysis and an EBC sample analyzed for NO(2)(-) using a spectrophotometric assay. Furthermore at the first and the last visit a chest radiograph was done and scored (Chrispin-Norman (CN) score). There was no correlation of EBC-NO(2)(-) and parameters of spirometry, SK-score, or CN-score. Furthermore, increased EBC-NO(2)(-) levels did not predict subsequent pulmonary exacerbations. We conclude that repeated measurements of EBC-NO(2)(-) are not helpful in the longitudinal monitoring of mild CF lung disease in children.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent - administration & dosage
- Adult - administration & dosage
- Breath Tests - methods
- Child - administration & dosage
- Cystic Fibrosis - diagnosis, metabolism, physiopathology
- Exhalation - administration & dosage
- Follow-Up Studies - administration & dosage
- Humans - administration & dosage
- Lung Diseases - diagnosis, metabolism, physiopathology
- Nitric Oxide - metabolism
- Prognosis - administration & dosage
- Radiography, Thoracic - administration & dosage
- Severity of Illness Index - administration & dosage
- Find related publications in this database (Keywords)
- NO-metabolites
- exhaled breath condensate
- CF
- longitudinal
- monitoring
- children