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Abbas, C; Singer, F; Yammine, S; Casaulta, C; Latzin, P.
Treatment response of airway clearance assessed by single-breath washout in children with cystic fibrosis.
J Cyst Fibros. 2013; 12(6):567-74 Doi: 10.1016/j.jcf.2013.05.010
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Leading authors Med Uni Graz: Singer Florian
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Abstract:: BACKGROUND: We studied the ability of 4 single-breath gas washout (SBW) tests to measure immediate effects of airway clearance in children with CF. METHODS: 25 children aged 4-16 years with CF performed pulmonary function tests to assess short-term variability at baseline and response to routine airway clearance. Tidal helium and sulfur hexafluoride (double-tracer gas: DTG) SBW, tidal capnography, tidal and vital capacity nitrogen (N2) SBW and spirometry were applied. We analyzed the gasses' phase III slope (SnIII--normalized for tidal volume) and FEV1 from spirometry. RESULTS: SnIII from tidal DTG-SBW, SnIII from vital capacity N2-SBW, and FEV1 improved significantly after airway clearance. From these tests, individual change of SnIII from tidal DTG-SBW and FEV1 exceeded short-term variability in 10 and 6 children. CONCLUSIONS: With the tidal DTG-SBW, an easy and promising test for peripheral gas mixing efficiency, immediate pulmonary function response to airway clearance can be assessed in CF children.
Find related publications in this database (using NLM MeSH Indexing): Adolescent - administration & dosage; Child - administration & dosage; Child, Preschool - administration & dosage; Cystic Fibrosis - physiopathology, therapy; Female - administration & dosage; Humans - administration & dosage; Male - administration & dosage; Physical Therapy Modalities - administration & dosage; Pulmonary Ventilation - administration & dosage; Respiratory Function Tests - administration & dosage
Find related publications in this database (Keywords): Children; Cystic fibrosis; Respiratory function test; Physical therapy modalities; Pulmonary ventilation