Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Abbas, C; Singer, F; Yammine, S; Casaulta, C; Latzin, P.
Treatment response of airway clearance assessed by single-breath washout in children with cystic fibrosis.
J Cyst Fibros. 2013; 12(6):567-74
Doi: 10.1016/j.jcf.2013.05.010
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Singer Florian
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- Abstract:
- BACKGROUND: We studied the ability of 4 single-breath gas washout (SBW) tests to measure immediate effects of airway clearance in children with CF. METHODS: 25 children aged 4-16 years with CF performed pulmonary function tests to assess short-term variability at baseline and response to routine airway clearance. Tidal helium and sulfur hexafluoride (double-tracer gas: DTG) SBW, tidal capnography, tidal and vital capacity nitrogen (N2) SBW and spirometry were applied. We analyzed the gasses' phase III slope (SnIII--normalized for tidal volume) and FEV1 from spirometry. RESULTS: SnIII from tidal DTG-SBW, SnIII from vital capacity N2-SBW, and FEV1 improved significantly after airway clearance. From these tests, individual change of SnIII from tidal DTG-SBW and FEV1 exceeded short-term variability in 10 and 6 children. CONCLUSIONS: With the tidal DTG-SBW, an easy and promising test for peripheral gas mixing efficiency, immediate pulmonary function response to airway clearance can be assessed in CF children.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent - administration & dosage
- Child - administration & dosage
- Child, Preschool - administration & dosage
- Cystic Fibrosis - physiopathology, therapy
- Female - administration & dosage
- Humans - administration & dosage
- Male - administration & dosage
- Physical Therapy Modalities - administration & dosage
- Pulmonary Ventilation - administration & dosage
- Respiratory Function Tests - administration & dosage
- Find related publications in this database (Keywords)
- Children
- Cystic fibrosis
- Respiratory function test
- Physical therapy modalities
- Pulmonary ventilation