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Yammine, S; Singer, F; Gustafsson, P; Latzin, P.
Impact of different breathing protocols on multiple-breath washout outcomes in children.
J Cyst Fibros. 2014; 13(2):190-7 Doi: 10.1016/j.jcf.2013.08.010
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Co-authors Med Uni Graz: Singer Florian
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Abstract:: BACKGROUND: To standardize multiple-breath washout (MBW) measurements, 1L tidal volume (VT) protocols were suggested. The effect on MBW derived ventilation inhomogeneity (VI) indices is unclear. METHODS: We compared VI indices from free breathing MBW at baseline to 1L VT MBW performed in triplicates in 35 children (20 with CF). Mean (range) age was 12.8 (7.0-16.7) years, weight 42 (20-64) kg and height 151 (117-170) cm. RESULTS: Baseline lung clearance index (LCI) increased from mean (SD) 11.0 (2.2) to 13.0 (2.6), p = 0.011, in CF and from 6.8 (0.5) to 7.7 (1.4), p = 0.004, in controls. Moment ratio and Scond similarly increased. While change in VI indices was heterogeneous in individuals, decrease in functional residual capacity was most strongly associated with LCI increase. CONCLUSION: MBW protocols strongly influence measures of VI. The 1L VT MBW protocol leads to overestimation of VI and is not recommended in children.
Find related publications in this database (using NLM MeSH Indexing): Adolescent - administration & dosage; Breath Tests - methods; Child - administration & dosage; Comparative Effectiveness Research - administration & dosage; Cross-Sectional Studies - administration & dosage; Cystic Fibrosis - diagnosis, physiopathology, therapy; Female - administration & dosage; Humans - administration & dosage; Male - administration & dosage; Outcome Assessment, Health Care - methods, standards; Pulmonary Ventilation - administration & dosage; Reproducibility of Results - administration & dosage; Respiratory Function Tests - methods, standards; Severity of Illness Index - administration & dosage
Find related publications in this database (Keywords): Children; Cystic fibrosis; Respiratory function test; Lung physiology; Clinical use