Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Yammine, S; Singer, F; Gustafsson, P; Latzin, P.
Impact of different breathing protocols on multiple-breath washout outcomes in children.
J Cyst Fibros. 2014; 13(2):190-7
Doi: 10.1016/j.jcf.2013.08.010
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Singer Florian
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- BACKGROUND: To standardize multiple-breath washout (MBW) measurements, 1L tidal volume (VT) protocols were suggested. The effect on MBW derived ventilation inhomogeneity (VI) indices is unclear. METHODS: We compared VI indices from free breathing MBW at baseline to 1L VT MBW performed in triplicates in 35 children (20 with CF). Mean (range) age was 12.8 (7.0-16.7) years, weight 42 (20-64) kg and height 151 (117-170) cm. RESULTS: Baseline lung clearance index (LCI) increased from mean (SD) 11.0 (2.2) to 13.0 (2.6), p = 0.011, in CF and from 6.8 (0.5) to 7.7 (1.4), p = 0.004, in controls. Moment ratio and Scond similarly increased. While change in VI indices was heterogeneous in individuals, decrease in functional residual capacity was most strongly associated with LCI increase. CONCLUSION: MBW protocols strongly influence measures of VI. The 1L VT MBW protocol leads to overestimation of VI and is not recommended in children.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent - administration & dosage
- Breath Tests - methods
- Child - administration & dosage
- Comparative Effectiveness Research - administration & dosage
- Cross-Sectional Studies - administration & dosage
- Cystic Fibrosis - diagnosis, physiopathology, therapy
- Female - administration & dosage
- Humans - administration & dosage
- Male - administration & dosage
- Outcome Assessment, Health Care - methods, standards
- Pulmonary Ventilation - administration & dosage
- Reproducibility of Results - administration & dosage
- Respiratory Function Tests - methods, standards
- Severity of Illness Index - administration & dosage
- Find related publications in this database (Keywords)
- Children
- Cystic fibrosis
- Respiratory function test
- Lung physiology
- Clinical use