Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Husemann, K; Berg, N; Engel, J; Port, J; Joppek, C; Tao, Z; Singer, F; Schulz, H; Kohlhäufl, M.
Double tracer gas single-breath washout: reproducibility in healthy subjects and COPD.
Eur Respir J. 2014; 44(5):1210-22
Doi: 10.1183/09031936.00085713
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Singer Florian
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- The applicability and interpretation of inert tracer gas washout tests is hampered by the lack of feasible protocols and reproducibility data. We assessed feasibility, variability and reproducibility of a new easy to perform double tracer gas (DTG) single-breath washout (SBW) test and compared this with conventional nitrogen washouts. In 40 healthy nonsmokers and 20 patients with stable chronic obstructive pulmonary disease (COPD), we performed three N2 vital capacity SBWs, three N2 multiple-breath washouts and three tidal DTG-SBW tests. Follow-up was after 1 week, 1 month and 6 months. Main outcomes were the lung clearance index (LCI) (N2 multiple-breath washout), slope of phase III (dN2) (N2 vital capacity SBW) and slope of phase III (SIIIDTG) (DTG-SBW). In healthy subjects, mean±sd LCI at baseline was 6.94±0.61, dN2 0.99±0.42% N2 per litre and SIIIDTG -0.206±0.108 g·mol(-1)·L(-1). In COPD, LCI and dN2 were significantly higher (LCI 12.23±2.67, dN2 7.43±5.38% N2 per litre; p<0.001) and SIIIDTG significantly steeper (-0.653±0.428 g·mol(-1)·L(-1), p<0.001). Reproducibility was high for main outcome parameters: the intraclass correlation coefficient over 6 months was 0.77 (0.86 in COPD) for LCI, 0.82 (0.89) for dN2 and 0.83 (0.93) for SIIIDTG. The tidal DTG-SBW is a reproducible test in healthy and COPD subjects that seems attractive for use in routine clinical settings.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult - administration & dosage
- Aged - administration & dosage
- Aged, 80 and over - administration & dosage
- Breath Tests - methods
- Carbon Monoxide - chemistry
- Case-Control Studies - administration & dosage
- Female - administration & dosage
- Forced Expiratory Volume - administration & dosage
- Healthy Volunteers - administration & dosage
- Humans - administration & dosage
- Male - administration & dosage
- Middle Aged - administration & dosage
- Nitrogen - chemistry
- Plethysmography - administration & dosage
- Prospective Studies - administration & dosage
- Pulmonary Disease, Chronic Obstructive - diagnosis, physiopathology
- Reproducibility of Results - administration & dosage
- Respiratory Function Tests - administration & dosage
- Smoking - administration & dosage
- Spirometry - administration & dosage
- Tidal Volume - administration & dosage
- Treatment Outcome - administration & dosage
- Vital Capacity - administration & dosage
- Young Adult - administration & dosage