Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Egger, B; Jost, K; Anagnostopoulou, P; Yammine, S; Singer, F; Casaulta, C; Frey, U; Latzin, P.
Lung clearance index and moment ratios at different cut-off values in infant multiple-breath washout measurements.
Pediatr Pulmonol. 2016; 51(12):1373-1381
Doi: 10.1002/ppul.23483
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Singer Florian
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- Abstract:
- BACKGROUND: Multiple-breath washout (MBW) is increasingly used for infant lung function testing. Current guidelines recommend calculating lung clearance index (LCI) and functional residual capacity (FRC) at 2.5% of normalized tracer gas concentration, without clear recommendation for moment ratios (MR). Whether the 2.5% cut-off has the highest discriminative power to detect ventilation inhomogeneity in infants with lung diseases is unknown. METHODS: We used sulfur-hexafluoride MBW measurements from 32 infants with cystic fibrosis, 32 preterm infants, and 32 healthy controls at postmenstrual age of 41-54 weeks. We compared the discriminative power to detect pathological values above the upper limit of normal for 12 different cut-offs between 20% and 1.5% for first and second MR (MR1, MR2), LCI, and FRC. RESULTS: MR and LCI results changed significantly at different cut-offs. Mean MR2 in infants with cystic fibrosis increased from 2.4 to 7.2 units between 20% and 1.5% SF6 . The ability of MR and LCI to discriminate between health and disease increased significantly with lower cut-offs. The 1.5% cut-off showed highest discriminative power: in infants with cystic fibrosis pathological MR2 values were found in 27 out of 89 (30%) and for LCI in 28/89 (32%). In preterm infants, pathological MR2 values were detected in 39 out of 73 (53%), and for LCI in 35/73 (48%). FRC remained stable throughout the washout. CONCLUSION: In infants, the diagnostic performance of MBW strongly depends on the point of analysis. The cut-off with the highest discriminative power to detect ventilation inhomogeneity in infants with cystic fibrosis and after preterm birth was at 1.5% tracer gas concentration. Pediatr Pulmonol. 2016;51:1373-1381. © 2016 Wiley Periodicals, Inc.
- Find related publications in this database (using NLM MeSH Indexing)
- Breath Tests - administration & dosage
- Case-Control Studies - administration & dosage
- Cystic Fibrosis - physiopathology
- Female - administration & dosage
- Functional Residual Capacity - administration & dosage
- Humans - administration & dosage
- Infant - administration & dosage
- Infant, Extremely Premature - administration & dosage
- Infant, Premature - administration & dosage
- Lung - physiopathology
- Lung Diseases - physiopathology
- Male - administration & dosage
- Pulmonary Ventilation - administration & dosage
- Respiratory Function Tests - methods
- Find related publications in this database (Keywords)
- infant lung function
- multiple-breath washout
- lung clearance index
- moment ratios