Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Posch-Pertl, L; List, W; Michelitsch, M; Pinter-Hausberger, S; Berisha, B; Posch, F; Kloeckl, L; Renner, W; Weger, M.
Heme oxygenase-1 gene rs2071746 polymorphism in retinal vein occlusion.
Ophthalmic Genet. 2022; 43(5):627-632
Doi: 10.1080/13816810.2022.2092754
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Posch-Pertl Laura
- Co-Autor*innen der Med Uni Graz
- Berisha Bujar
- List Wolfgang Michael
- Michelitsch Monja
- Pinter-Hausberger Silke
- Posch Florian
- Renner Wilfried
- Weger Martin
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- Abstract:
- BACKGROUND: Heme oxygenase-1 (HO-1) is an important cytoprotective enzyme due to its ability to degrade pro-inflammatory heme. The common single nucleotide polymorphism (SNP) rs2071746 on the HMOX1 gene has been associated with HO-1 activity and a variety of cardiovascular diseases. This study was performed to investigate the association between the rs2071746 SNP and retinal vein occlusion (RVO). METHODS: We included 496 RVO patients and 297 control subjects in this case-control study. Genotypes of the rs2071746 polymorphism were determined by TaqMan assays. RESULTS: There was no association between the rs2071746 genotype and the presence of RVO (p = .443). The lack of association was found in all three logistic regression models, namely the dominant (p = .560), the recessive (p = .373) and the co-dominant model (p = .444). The distribution of the rs2071746 genotype was 30% (AA), 51% (AT), and 19% (TT). Baseline characteristics were similar between these genotypes, except for diabetes mellitus, which was less prevalent in the AA genotype (p < .001). CONCLUSION: The rs2071746 polymorphism does not seem to be a major risk factor for the presence of RVO.
- Find related publications in this database (Keywords)
- Heme oxygenase-1
- HO-1
- HMOX1
- polymorphism
- retinal vein occlusion
- RVO