Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Gabel, D; Preusse, D; Haritz, D; Grochulla, F; Haselsberger, K; Fankhauser, H; Ceberg, C; Peters, HD; Klotz, U.
Pharmacokinetics of Na2B12H11SH (BSH) in patients with malignant brain tumours as prerequisite for a phase I clinical trial of boron neutron capture.
Acta Neurochir (Wien). 1997; 139(7):606-611
Doi: 10.1007/BF01411994
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Haselsberger Klaus
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- The disposition of Na2B12H11SH (BSH) in patients with malignant glioma has been investigated, in preparation for a Phase I clinical trial of boron neutron capture therapy. BSH was found to possess a linear disposition over the dosage interval investigated (up to 75 mg/kg). A bi-phasic blood pharmacokinetics was observed. Tumour-to-blood ratios showed variations between patients between 0.08 and 5.1. The data allow the definition of amount of BSH and timing of infusion for a Phase I clinical trial protocol.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Borohydrides - pharmacokinetics
- Boron Neutron Capture Therapy - pharmacokinetics
- Brain Neoplasms - radiotherapy
- Female - radiotherapy
- Glioma - radiotherapy
- Humans - radiotherapy
- Male - radiotherapy
- Middle Aged - radiotherapy
- Find related publications in this database (Keywords)
- Boron Neutron Capture Therapy
- Bsh
- Glioma