Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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Port, J; Tao, Z; Junger, A; Joppek, C; Tempel, P; Husemann, K; Singer, F; Latzin, P; Yammine, S; Nagel, JH; Kohlhäufl, M.
A simple method to reconstruct the molar mass signal of respiratory gas to assess small airways with a double-tracer gas single-breath washout.
Med Biol Eng Comput. 2017; 55(11):1975-1987
Doi: 10.1007/s11517-017-1633-y
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- Co-Autor*innen der Med Uni Graz
- Singer Florian
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- Abstract:
- For the assessment of small airway diseases, a noninvasive double-tracer gas single-breath washout (DTG-SBW) with sulfur hexafluoride (SF6) and helium (He) as tracer components has been proposed. It is assumed that small airway diseases may produce typical ventilation inhomogeneities which can be detected within one single tidal breath, when using two tracer components. Characteristic parameters calculated from a relative molar mass (MM) signal of the airflow during the washout expiration phase are analyzed. The DTG-SBW signal is acquired by subtracting a reconstructed MM signal without tracer gas from the signal measured with an ultrasonic sensor during in- and exhalation of the double-tracer gas for one tidal breath. In this paper, a simple method to determine the reconstructed MM signal is presented. Measurements on subjects with and without obstructive lung diseases including the small airways have shown high reliability and reproducibility of this method.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult - administration & dosage
- Airway Obstruction - diagnosis, metabolism
- Child - administration & dosage
- Helium - metabolism
- Humans - administration & dosage
- Lung - metabolism
- Pulmonary Disease, Chronic Obstructive - diagnosis, metabolism
- Pulmonary Ventilation - physiology
- Reproducibility of Results - administration & dosage
- Respiration - administration & dosage
- Sulfur Hexafluoride - metabolism
- Tidal Volume - physiology
- Find related publications in this database (Keywords)
- Small airway diseases
- Double-tracer gas single-breath washout (DTG-SBW)
- Signal reconstruction
- OLS