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Nyilas, S; Bigler, A; Yammine, S; Kieninger, E; Rochat, I; Ramsey, K; Casaulta, C; Moeller, A; Latzin, P; Singer, F.
Alternate gas washout indices: Assessment of ventilation inhomogeneity in mild to moderate pediatric cystic fibrosis lung disease.
Pediatr Pulmonol. 2018; 53(11):1485-1491 Doi: 10.1002/ppul.24149
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Leading authors Med Uni Graz: Singer Florian
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Abstract:: INTRODUCTION: Normalized phase III slope (Sn_III ) indices from multiple breath washout (MBW) estimate ventilation inhomogeneity. Alternate (*) protocols for Sn_III indices exist, however the utility of these outcomes in children with mild-to-moderate cystic fibrosis (CF) is unknown. METHODS: We measured nitrogen MBW and spirometry in 135 children (43 controls) aged 4-18 years. We assessed validity, practicability, and reliability of Sn_III protocols. Outcomes included the ability to detect abnormal lung function, test agreement, measurement duration, intra-test repeatability, and quality. RESULTS: Lung clearance index (LCI) was abnormal in 80 (87%), Scond in 55 (60%), Scond* in 17 (19%), Sacin in 10 (11%), Sacin* in 11 (12%), and FEV₁ in 28 (30%). Alternate protocols reduced measurement duration. Agreement of indices to detect abnormal lung function was poor. The quality of analysis and repeatability deteriorated with the alternate technique compared to standard. CONCLUSION: In children with mild-to-moderate CF lung disease, alternate protocols seem practical but clinimetric properties of standard Sn_III protocols are preferable.
Find related publications in this database (using NLM MeSH Indexing): Adolescent - administration & dosage; Child - administration & dosage; Child, Preschool - administration & dosage; Cystic Fibrosis - physiopathology; Female - administration & dosage; Humans - administration & dosage; Lung - physiopathology; Male - administration & dosage; Reproducibility of Results - administration & dosage; Respiration - administration & dosage; Respiratory Function Tests - methods
Find related publications in this database (Keywords): child; cystic fibrosis; lung function tests