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SHR Neuro Cancer Cardio Lipid Metab Microb
Roberts, G; Fontanella, S; Selby, A; Howard, R; Filippi, S; Hedlin, G; Nordlund, B; Howarth, P; Hashimoto, S; Brinkman, P; Fleming, LJ; Murray, C; Bush, A; Frey, U; Singer, F; Schoos, AM; van, Aalderen, W; Djukanovic, R; Chung, KF; Sterk, PJ; Adnan, C, , U-BIOPRED, Consortium.
Connectivity patterns between multiple allergen specific IgE antibodies and their association with severe asthma.
J Allergy Clin Immunol. 2020; 146(4):821-830
Doi: 10.1016/j.jaci.2020.02.031
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Singer Florian
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- Abstract:
- BACKGROUND: Allergic sensitization is associated with severe asthma, but assessment of sensitization is not recommended by most guidelines. OBJECTIVE: We hypothesized that patterns of IgE responses to multiple allergenic proteins differ between sensitized participants with mild/moderate and severe asthma. METHODS: IgE to 112 allergenic molecules (components, c-sIgE) was measured using multiplex array among 509 adults and 140 school-age and 131 preschool children with asthma/wheeze from the Unbiased BIOmarkers for the PREDiction of respiratory diseases outcomes cohort, of whom 595 had severe disease. We applied clustering methods to identify co-occurrence patterns of components (component clusters) and patterns of sensitization among participants (sensitization clusters). Network analysis techniques explored the connectivity structure of c-sIgE, and differential network analysis looked for differences in c-sIgE interactions between severe and mild/moderate asthma. RESULTS: Four sensitization clusters were identified, but with no difference between disease severity groups. Similarly, component clusters were not associated with asthma severity. None of the c-sIgE were identified as associates of severe asthma. The key difference between school children and adults with mild/moderate compared with those with severe asthma was in the network of connections between c-sIgE. Participants with severe asthma had higher connectivity among components, but these connections were weaker. The mild/moderate network had fewer connections, but the connections were stronger. Connectivity between components with no structural homology tended to co-occur among participants with severe asthma. Results were independent from the different sample sizes of mild/moderate and severe groups. CONCLUSIONS: The patterns of interactions between IgE to multiple allergenic proteins are predictors of asthma severity among school children and adults with allergic asthma.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent - administration & dosage
- Adult - administration & dosage
- Age Factors - administration & dosage
- Aged - administration & dosage
- Allergens - immunology
- Antibody Specificity - immunology
- Asthma - diagnosis, immunology
- Biomarkers - administration & dosage
- Body Mass Index - administration & dosage
- Child - administration & dosage
- Child, Preschool - administration & dosage
- Cluster Analysis - administration & dosage
- Europe - administration & dosage
- Female - administration & dosage
- Humans - administration & dosage
- Immunization - administration & dosage
- Immunoglobulin E - immunology
- Male - administration & dosage
- Middle Aged - administration & dosage
- Prognosis - administration & dosage
- Severity of Illness Index - administration & dosage
- Young Adult - administration & dosage
- Find related publications in this database (Keywords)
- Asthma
- allergic sensitization
- cluster
- network analysis