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Kurz, JM; Ramsey, KA; Rodriguez, R; Spycher, B; Fischer, Biner, R; Latzin, P; Singer, F.
Association of lung clearance index with survival in individuals with cystic fibrosis.
Eur Respir J. 2022; 59(3): Doi: 10.1183/13993003.00432-2021
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Leading authors Med Uni Graz: Singer Florian
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Abstract:: BACKGROUND: The lung clearance index (LCI) assesses global ventilation inhomogeneity and is a sensitive biomarker of airway function in cystic fibrosis (CF) lung disease. We examined the association of LCI with the risk of death or lung transplantation (LTx) in individuals with CF. METHODS: We performed a retrospective analysis in a cohort of individuals with CF aged ≥5 years with LCI and forced expired volume in 1 s (FEV₁) measurements performed between 1980 and 2006. The outcome was time until death or LTx. We used the earliest available LCI and FEV₁ values in a Cox proportional hazards regression adjusted for demographic and clinical variables. For sensitivity analyses, we used the mean of the first three LCI and FEV₁ measurements, stratified the cohort based on age, and investigated individuals with normal FEV₁. RESULTS: In total, 237 individuals with CF with a mean (range) age of 13.9 (5.6-41.0) years were included. The time-to-event analysis accrued 3813 person-years and 94 (40%) individuals died or received LTx. Crude hazard ratios were 1.04 (95% CI 1.01-1.06) per 1.0 z-score increase in LCI and 1.25 (95% CI 1.11-1.41) per 1.0 z-score decrease in FEV₁. After adjusting LCI and FEV₁ mutually in addition to sex, age, body mass index and number of hospitalisations, hazard ratios were 1.04 (95% CI 1.01-1.07) for LCI and 1.12 (95% CI 0.95-1.33) for FEV₁. Sensitivity analyses yielded similar results and using the mean LCI strengthened the associations. CONCLUSIONS: Increased ventilation inhomogeneity is associated with greater risk of death or LTx. Our data support LCI as novel surrogate of survival in individuals with CF.
Find related publications in this database (using NLM MeSH Indexing): Adolescent - administration & dosage; Adult - administration & dosage; Child, Preschool - administration & dosage; Cystic Fibrosis - administration & dosage; Forced Expiratory Volume - administration & dosage; Humans - administration & dosage; Lung - administration & dosage; Respiratory Function Tests - administration & dosage; Retrospective Studies - administration & dosage; Young Adult - administration & dosage