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SHR Neuro Cancer Cardio Lipid Metab Microb

Hoeller, N; Wolfsberger, CH; Pfurtscheller, D; Binder-Heschl, C; Schwaberger, B; Urlesberger, B; Pichler, G.
pFOE or pFTOE as an Early Marker for Impaired Peripheral Microcirculation in Neonates.
Children (Basel). 2022; 9(6): Doi: 10.3390/children9060898 [OPEN ACCESS]
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Leading authors Med Uni Graz: Höller Nina
Co-authors Med Uni Graz: Binder-Heschl Corinna; Pfurtscheller Daniel; Pichler Gerhard; Schwaberger Bernhard; Urlesberger Berndt; Wolfsberger Christina Helene
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Abstract:: BACKGROUND: Peripheral-muscle-fractional-oxygen-extraction (pFOE) and peripheral-muscle-fractional-tissue-oxygen-extraction (pFTOE) are often equated, since both parameters are measured with near-infrared-spectroscopy (NIRS) and estimate oxygen extraction in the tissue. The aim was to investigate the comparability of both parameters and their potential regarding detection of impaired microcirculation. METHODS: Term and preterm neonates with NIRS measurements of upper (UE) and lower extremities (LE) were included. pFOE was calculated out of peripheral-muscle-mixed-venous-saturation (pSvO₂), measured with NIRS and venous occlusion, and arterial oxygen saturation (SpO₂). pFTOE was calculated out of peripheral-muscle-tissue-oxygen-saturation and SpO₂. Both parameters were compared using Wilcoxon-Signed-Rank-test and Bland-Altman plots. RESULTS: 341 NIRS measurements were included. pFOE was significantly higher than pFTOE in both locations. Bland-Altman plots revealed limited comparability, especially with increasing oxygen extraction with higher values of pFOE compared to pFTOE. CONCLUSION: The higher pFOE compared to pFTOE suggests a higher potential of pFOE to detect impaired microcirculation, especially when oxygen extraction is elevated.
Find related publications in this database (Keywords): peripheral muscle; fractional oxygen extraction; near-infrared spectroscopy; neonates; microcirculation