Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Tuca, AC; Bernardelli, de, Mattos, I; Funk, M; Winter, R; Palackic, A; Groeber-Becker, F; Kruse, D; Kukla, F; Lemarchand, T; Kamolz, LP.
Orchestrating the Dermal/Epidermal Tissue Ratio during Wound Healing by Controlling the Moisture Content.
Biomedicines. 2022; 10(6): 1286
Doi: 10.3390/biomedicines10061286
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- Führende Autor*innen der Med Uni Graz
- Tuca Alexandru
- Co-Autor*innen der Med Uni Graz
- Kamolz Lars-Peter
- Palackic Alen
- Winter Raimund
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- Abstract:
- A balanced and moist wound environment and surface increases the effect of various growth factors, cytokines, and chemokines, stimulating cell growth and wound healing. Considering this fact, we tested in vitro and in vivo water evaporation rates from the cellulose dressing epicitehydro when combined with different secondary dressings as well as the resulting wound healing efficacy in a porcine donor site model. The aim of this study was to evaluate how the different rates of water evaporation affected wound healing efficacy. To this end, epicitehydro primary dressing, in combination with different secondary dressing materials (cotton gauze, JELONET◊, AQUACEL® Extra ™, and OPSITE◊ Flexifix), was placed on 3 × 3 cm-sized dermatome wounds with a depth of 1.2 mm on the flanks of domestic pigs. The healing process was analyzed histologically and quantified by morphometry. High water evaporation rates by using the correct secondary dressing, such as cotton gauze, favored a better re-epithelialization in comparison with the low water evaporation resulting from an occlusive secondary dressing, which favored the formation of a new and intact dermal tissue that nearly fully replaced all the dermis that was removed during wounding. This newly available evidence may be of great benefit to clinical wound management.
- Find related publications in this database (Keywords)
- bacterial cellulose dressing
- secondary wound dressing
- moisture balance
- wound healing
- in vivo experiments