Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Luze, H; Schwarz, A; Philipp, Nischwitz, S; Kolb, D; Bounab, K; Zrim, R; Winter, R; Kamolz, LP; Rappl, T; Kotzbeck, P.
Autologous Fat Grafting in Reconstructive Breast Surgery: Clinically Relevant Factors Affecting the Graft Take.
Aesthet Surg J. 2022; 42(12):NP745-NP755
Doi: 10.1093/asj/sjac166
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Luze Hanna
- Co-Autor*innen der Med Uni Graz
- Bounab Kaddour
- Kamolz Lars-Peter
- Kolb Dagmar
- Kotzbeck Petra
- Nischwitz Sebastian
- Rappl Thomas
- Schwarz Anna
- Winter Raimund
- Zrim Robert
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- Abstract:
- BACKGROUND: Autologous fat grafting is an effective tool for soft tissue augmentation in reconstructive breast surgery. Despite the major advantages of this minimally invasive approach, the unpredictability of graft survival presents challenges. OBJECTIVES: No clear consensus on the optimal technique has yet been published and well-defined prospective studies investigating impairing factors are lacking. This aim of this study was to generate valuable fundamental data. METHODS: Ten female patients undergoing elective autologous fat grafting after nipple-sparing mastectomy were enrolled. Punch biopsies and lipoaspirates were collected from the harvest site for histologic, gene expression, and scanning electron microscopic analysis. Noninvasive Lipometer measurements determining the subcutaneous adipose tissue thickness at the graft site were used to calculate the respective take rate. Patient- and surgery-related data were acquired and correlated with the take rate. RESULTS: A statistically relevant correlation between the take rate and the existing mean subcutaneous adipose tissue thickness at the grafted breast prior to surgery was observed. An approximate correlation was identified regarding the number of previous grafting sessions, body weight, and BMI. No statistically significant correlation was demonstrated for age, harvest site, or the mean adipocyte size. A lower level of cell damage was observed in scanning electron microscopic samples of washed lipoaspirates; and a strong indirect correlation with the expression of the adipocyte markers FABP4 and PLIN1 was apparent. CONCLUSIONS: Factors correlating to the take rate were identified. Future studies investigating the clinical relevance of each impairing factor are essential to contribute to the optimization of this valuable method.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Female - administration & dosage
- Mammaplasty - methods
- Mastectomy - administration & dosage
- Prospective Studies - administration & dosage
- Breast Neoplasms - administration & dosage
- Adipose Tissue - transplantation
- Transplantation, Autologous - methods
- Graft Survival - administration & dosage