Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Klimek, L; Hagemann, J; Welkoborsky, HJ; Cuevas, M; Casper, I; Forster-Ruhrmann, U; Klimek, F; Hintschich, CA; Hupperti, T; Bergmann, C; Tomazic, PV; Becker, S.
Epitheliale Immunregulation entz?ndlicher Atemwegserkrankungen am Beispiel der Chronischen Rhinosinusitis (CRS)
ALLERGOLOGIE. 2022; 45(5): 334-354.
Doi: 10.5414/ALX02296E
Web of Science
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- Co-authors Med Uni Graz
- Tomazic Peter Valentin
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- Abstract:
- Background: The epithelial immune regulation is an essential and protective feature of the barrier function in the area of the mucous membranes of the airways. Damage to the epithelial barrier can result in chronic inflammatory diseases, such as chronic rhino sinusitis (CRS) or bronchial asthma. The thymic stromal lymphopoietin (TSLP) is a central regulator in the epithelial barrier function and is associated with type 2 and non-type 2 and guideline registers and the Cochrane Library. Human studies or studies on human cells that were published between 2010 and 2020 and in which the immune mechanisms of TSLP in type 2 and non-type 2 inflammation were examined were considered. Result: TSLP is an epithelial cytokine (alarmin) and a central regulator of the immune reaction, especially in the case of chronic airway inflammation. Induction of TSLP is implicated in the pathogenesis of many diseases like CRS and triggers a cascade of subsequent inflammatory reactions. Conclusion: Treatment with TSLP-blocking monoclonal antibodies could therefore open up interesting therapeutic options. The long-term safety and effectiveness of TSLP blockade has yet to be investigated.
- Find related publications in this database (Keywords)
- alarmine
- CRS
- CRSwNP
- epithelial immune regu-lation
- T2-inflammation
- Tezepelumab
- TSLP