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SHR Neuro Cancer Cardio Lipid Metab Microb
Bracic, T; Reich, O; Taumberger, N; Tamussino, K; Trutnovsky, G.
Does mode of delivery impact the course of cervical dysplasia in pregnancy? A review of 219 cases.
Eur J Obstet Gynecol Reprod Biol. 2022; 274:13-18
Doi: 10.1016/j.ejogrb.2022.05.002
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Bracic Taja
- Co-authors Med Uni Graz
- Reich Olaf
- Tamussino Karl
- Taumberger Nadja
- Trutnovsky Gerda
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- Abstract:
- OBJECTIVE: The prevalence of cervical intraepithelial neoplasia (CIN) in pregnancy is about 1%. The aim of this study was to analyze the regression, persistence and progression rates of cervical dysplasia in pregnancy and the impact of delivery mode. STUDY DESIGN: In this retrospective study, data from pregnant patients with abnormal cytology findings, who presented to a colposcopic outpatient clinic of a university hospital within the last 10 years, were analyzed. Information on cytology, histology and Human Papillomavirus (HPV) status during pregnancy and postpartum and mode of delivery was collected. RESULTS: 219 women, who were assessed with cytology and /or biopsy antepartum and postpartum between January 2010 and July 2020, were included in the study. Antepartum patients presented with low grade squamous intraepithelial lesions (LSIL) in 37% and high grade squamous intraepithelial lesions (HSIL) in 53%. During pregnancy biopsy was performed in 78 patients (36%). Postpartum evaluation revealed an overall regression rate of 39%. Persistence rates were especially high in the HSIL group with 70 %. HSIL regressed in 28 %. Progression to invasive disease was rare and seen in two patients postpartum only. 141 women delivered vaginally (VD) and 51 received a cesarean section (CS). Regression rates were similar: 36 % and 47 %. There was no significant difference in progression or persistence rates. CONCLUSION: Our study demonstrates that mode of delivery does not influence the course of SIL. SIL show high rates of regression and persistence, progression to invasive disease is rare.
- Find related publications in this database (using NLM MeSH Indexing)
- Cervical Intraepithelial Neoplasia - pathology
- Cesarean Section - administration & dosage
- Colposcopy - administration & dosage
- Female - administration & dosage
- Humans - administration & dosage
- Papillomavirus Infections - pathology
- Pregnancy - administration & dosage
- Pregnancy Complications, Neoplastic - epidemiology, pathology
- Retrospective Studies - administration & dosage
- Uterine Cervical Dysplasia - epidemiology
- Uterine Cervical Neoplasms - epidemiology, pathology
- Vaginal Smears - administration & dosage
- Find related publications in this database (Keywords)
- Cervical dysplasia
- Mode of delivery
- HSIL
- Pregnancy
- Regression