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SHR Neuro Cancer Cardio Lipid Metab Microb

Jantscher-Krenn, E; von, Schirnding, L; Trötzmüller, M; Köfeler, H; Kurtovic, U; Fluhr, H; Müller, A; Bagci, S.
Human Milk Oligosaccharides Are Present in Amniotic Fluid and Show Specific Patterns Dependent on Gestational Age.
Nutrients. 2022; 14(10): Doi: 10.3390/nu14102065 [OPEN ACCESS]
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Leading authors Med Uni Graz: Jantscher-Krenn Evelyn
Co-authors Med Uni Graz: Fluhr Herbert; Köfeler Harald; Trötzmüller Martin
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Abstract:: (1) Background: Human milk oligosaccharides (HMOs) are already found in maternal circulation in early pregnancy, changing with gestational age. HMOs are also present in cord blood and amniotic fluid (AF). We aimed to assess HMO profiles in AF over the course of gestation. (2) Methods: AF was collected during diagnostic amniocentesis, fetal surgery, or C-section from 77 women with a gestational age of ranging from 14.3 to 40.9 weeks. Samples were analysed using high performance liquid chromatography with fluorescence detection. (3) Results: We found lactose and up to 16 HMO structures in all AF samples investigated, starting at 14 weeks of gestation. Overall, 3'-sialyllactose (3'SL) and 2'-fucosyllactose (2'FL) were the most abundant HMOs. Individual and total HMO concentrations were significantly positively correlated with gestational age. HMO composition also changed between early, mid- and late pregnancy, with relative concentrations of 3'SL significantly decreasing (44%, 25%, 24%) and 2'FL increasing (7%, 13%, 21%), respectively. (4) Conclusion: Our study shows that HMOs are already present in AF early in pregnancy. This demonstrates extensive contact of the fetus with a broad variety of HMOs, suggesting roles for HMOs in fetal tissue development during the time course of pregnancy.
Find related publications in this database (Keywords): pregnancy; human milk oligosaccharides (HMOs); amniotic fluid; preterm nutrition; 2 '-fucosyllactose; lactose; amniocentesis; fetal surgery