Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Nussbaumer, G; Benesch, M.
Hepatoblastoma in molecularly defined, congenital diseases.
Am J Med Genet A. 2022; 188(9):2527-2535
Doi: 10.1002/ajmg.a.62767
[OPEN ACCESS]
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- Leading authors Med Uni Graz
- Nussbaumer Gunther
- Co-authors Med Uni Graz
- Benesch Martin
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- Abstract:
- Beckwith-Wiedemann spectrum, Simpson-Golabi-Behmel syndrome, familial adenomatous polyposis and trisomy 18 are the most common congenital conditions associated with an increased incidence of hepatoblastoma (HB). In patients with these genetic disorders, screening protocols for HB are proposed that include periodic abdominal ultrasound and measurement of alpha-fetoprotein levels. Surveillance in these children may contribute to the early detection of HB and possibly improve their chances of overall survival. Therefore, physicians must be aware of the high HB incidence in children with certain predisposing genetic diseases.
- Find related publications in this database (using NLM MeSH Indexing)
- Beckwith-Wiedemann Syndrome - diagnosis, epidemiology, genetics
- Child - administration & dosage
- Genetic Diseases, X-Linked - genetics
- Gigantism - genetics
- Hepatoblastoma - diagnosis, epidemiology, genetics
- Humans - administration & dosage
- Liver Neoplasms - complications, diagnosis, genetics
- Find related publications in this database (Keywords)
- cancer predisposition
- congenital diseases
- hepatoblastoma
- screening
- surveillance