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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Pavlidis, P; Gouveris, H; Nikolaidis, V; Schittek, G.
Changes of Serum Levels of Caspase-3 after Trauma and Ototoxic Damage of the Cochlea in Rabbits: An in vivo Study
INDIAN J OTOL. 2022; 28(1): 52-56. Doi: 10.4103/indianjotol.indianjotol_29_22
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- Co-authors Med Uni Graz
- Schittek Gregor Alexander
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- Abstract:
- Background: Caspase-3 is one of the most important enzymes for the regulation of apoptosis. Aims and Objectives: Aim of our study was to examine the changes in serum levels of this factor during apoptotic phenomena in the cochlea, caused by traumatic or ototoxic causes. Materials and Methods: A cohort of 24 rabbits was studied for this purpose for 31 days. Eight animals were implanted with a cochlear implant electrode (group A), 8 were treated with intramuscular amikacin for 14 days (group B) and another 8 were the control group (group C). In all groups DPOAEs and serum levels of caspase-3 were tested every second day. Results: Serum levels of caspase-3 rise immediately after implantation, while a 3-day latency in levels was seen in group B. Caspase-3-levels in both groups remained elevated until the 31st day of the experiment. Levels of caspase-3 showed a moderate negative correlation with DPAOE amplitudes. Conclusion: Caspase-3 rises after traumatic and ototoxic causes and moderately correlates with cochlear outer hair cell function in rabbits. Therefore, serum caspase-3 levels should be tested as a surrogate marker of structural integrity of the cochlea after trauma or administration of ototoxic drugs in humans as well.
- Find related publications in this database (Keywords)
- Apoptosis
- biomarker
- Caspases-3
- cochlear implant
- distortion products otoacoustic emissions
- ototoxicity