Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Silvagni, E; Zandonella, Callegher, S; Mauric, E; Chiricolo, S; Schreiber, N; Tullio, A; Zabotti, A; Scirè, CA; Dejaco, C; Sakellariou, G.
Musculoskeletal ultrasound for treating rheumatoid arthritis to target-a systematic literature review.
Rheumatology (Oxford). 2022; 61(12):4590-4602
Doi: 10.1093/rheumatology/keac261
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Dejaco Christian
- Schreiber Nikolaus
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- OBJECTIVE: We aimed to systematically review the literature to retrieve evidence on the diagnostic and prognostic value of musculoskeletal ultrasound for a treat to target (T2T) approach in RA. METHODS: Eight research questions were developed addressing the role of ultrasound (including different ultrasound scores and elementary lesions) for diagnosis, monitoring and prognosis of RA. PubMed and EMBASE were searched (2005-2020). Articles on RA and reporting data on musculoskeletal ultrasound were included and extracted according to the underlying questions, and risk of bias assessed according to the study design. RESULTS: Out of 4632 records, 60 articles were included. Due to clinical heterogeneity, meta-analysis was not possible. Ultrasound better predicted disease relapses with respect to clinical examination in patients in remission, while both methods performed similarly in predicting response to therapy, achievement of remission and radiographic progression. Ultrasound was superior to clinical examination in diagnosing joint involvement using another imaging modality, such as magnetic resonance imaging, as reference. Limited ultrasound scores performed like more extensive evaluations for the detection of joint inflammation and for outcome prediction. Higher ultrasound scores of synovitis were linked to poor outcomes at all disease stages, but a specific cut-off distinguishing between low- and high-risk groups did not emerge. CONCLUSIONS: These data confirm the pivotal role of ultrasound when evaluating synovial inflammation and when identifying RA patients at higher risk of relapse. Further research is needed to better define the role of ultrasound in a T2T management strategy in moderately-to-highly active RA.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Arthritis, Rheumatoid - diagnostic imaging, therapy
- Synovitis - therapy, drug therapy
- Ultrasonography - administration & dosage
- Prognosis - administration & dosage
- Recurrence - administration & dosage
- Inflammation - administration & dosage
- Find related publications in this database (Keywords)
- RA
- imaging
- ultrasound
- diagnosis
- prognosis
- prediction
- systematic literature review