Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Frid, P; Xu, H; Mitchell, BD; Drake, M; Wasselius, J; Gaynor, B; Ryan, K; Giese, AK; Schirmer, M; Donahue, KL; Irie, R; Bouts, MJRJ; McIntosh, EC; Mocking, SJT; Dalca, AV; Giralt-Steinhauer, E; Holmegaard, L; Jood, K; Roquer, J; Cole, JW; McArdle, PF; Broderick, JP; Jimenez-Conde, J; Jern, C; Kissela, BM; Kleindorfer, DO; Lemmens, R; Meschia, JF; Rosand, J; Rundek, T; Sacco, RL; Schmidt, R; Sharma, P; Slowik, A; Thijs, V; Woo, D; Worrall, BB; Kittner, SJ; Petersson, J; Golland, P; Wu, O; Rost, NS; Lindgren, A.
Migraine-associated common genetic variants confer greater risk of posterior vs. anterior circulation ischemic stroke☆.
J Stroke Cerebrovasc Dis. 2022; 31(8): 106546 Doi: 10.1016/j.jstrokecerebrovasdis.2022.106546 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Co-authors Med Uni Graz: Schmidt Reinhold
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: OBJECTIVE: To examine potential genetic relationships between migraine and the two distinct phenotypes posterior circulation ischemic stroke (PCiS) and anterior circulation ischemic stroke (ACiS), we generated migraine polygenic risk scores (PRSs) and compared these between PCiS and ACiS, and separately vs. non-stroke control subjects. METHODS: Acute ischemic stroke cases were classified as PCiS or ACiS based on lesion location on diffusion-weighted MRI. Exclusion criteria were lesions in both vascular territories or uncertain territory; supratentorial PCiS with ipsilateral fetal posterior cerebral artery; and cases with atrial fibrillation. We generated migraine PRS for three migraine phenotypes (any migraine; migraine without aura; migraine with aura) using publicly available GWAS data and compared mean PRSs separately for PCiS and ACiS vs. non-stroke control subjects, and between each stroke phenotype. RESULTS: Our primary analyses included 464 PCiS and 1079 ACiS patients with genetic European ancestry. Compared to non-stroke control subjects (n=15396), PRSs of any migraine were associated with increased risk of PCiS (p=0.01-0.03) and decreased risk of ACiS (p=0.010-0.039). Migraine without aura PRSs were significantly associated with PCiS (p=0.008-0.028), but not with ACiS. When comparing PCiS vs. ACiS directly, migraine PRSs were higher in PCiS vs. ACiS for any migraine (p=0.001-0.010) and migraine without aura (p=0.032-0.048). Migraine with aura PRS did not show a differential association in our analyses. CONCLUSIONS: Our results suggest a stronger genetic overlap between unspecified migraine and migraine without aura with PCiS compared to ACiS. Possible shared mechanisms include dysregulation of cerebral vessel endothelial function.
Find related publications in this database (Keywords): Posterior circulation ischemic stroke; MRI phenotype; Migraine; Common genetic variants