Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hawliczek, A; Brix, B; Al Mutawa, S; Alsuwaidi, H; Du Plessis, S; Gao, YF; Qaisar, R; Siddiqui, R; Elmoselhi, AB; Goswami, N.
Hind-limb unloading in rodents: Current evidence and perspectives
ACTA ASTRONAUT. 2022; 195: 574-582.
Doi: 10.1016/j.actaastro.2022.03.008
Web of Science
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- Führende Autor*innen der Med Uni Graz
- Goswami Nandu
- Hawliczek Anna Adela
- Co-Autor*innen der Med Uni Graz
- Steuber Bianca
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- Abstract:
- Due to scarcity of available biological samples from returning space explorers, alternative models, which improve the understanding of spaceflight-related pathophysiology are needed. This review presents an update of available literature on the hind-limb unloading model (HLU). HLU has been used as a model to simulating microgravity in rodents since the early 1980s. This model, by removing the gravitational load from hind limbs of the animals, is widely used for studying the effects of the hindlimb unloading on the cardiovascular and musculoskeletal physiology. Recent updates in the literature with regards to HLU, its advantages as well as how this model can be used to understand the effects of bedrest confinement and/or spaceflight are provided.
- Find related publications in this database (Keywords)
- Hind-limb unloading model
- Microgravity
- Musculoskeletal changes
- Cardiovascular changes
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- Stress
- Microbiome