Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Chao, GF; Krishna, N; Aizer, AA; Dalela, D; Hanske, J; Li, H; Meyer, CP; Kim, SP; Mahal, BA; Reznor, G; Schmid, M; Choueiri, TK; Nguyen, PL; O'Leary, M; Trinh, QD.
Asian Americans and prostate cancer: A nationwide population-based analysis.
Urol Oncol. 2016; 34(5):233.e7-15
Doi: 10.1016/j.urolonc.2015.11.013
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Leitsmann Marianne
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- Abstract:
- INTRODUCTION: It remains largely unknown if there are racial disparities in outcomes of prostate cancer (PCa) for Asian American and Pacific Islanders (PIs) (AAPIs). We examined differences in diagnosis, management, and survival of AAPI ethnic groups, relative to their non-Hispanic White (NHW) counterparts. METHODS: Patients (n = 891,100) with PCa diagnosed between 1988 and 2010 within the surveillance, epidemiology, and end results database were extracted and stratified by ethnic group: Chinese, Japanese, Filipino, Hawaiian, Korean, Vietnamese, Asian Indian/Pakistani, PI, and Other Asian. The effect of ethnic group on stage at presentation, rates of definitive treatment, and PCa-specific mortality was assessed. The severity at diagnosis was defined as: localized (TxN0M0), regional (TxN1M0), or metastatic (TxNxM1). RESULTS: Relative to NHWs, Asian Indian/Pakistani, Filipino, Hawaiian, and PI men had significantly worse outcomes. Filipino (odds ratio [OR] = 1.38, 95% CI: 1.27-1.51), Hawaiian, (OR = 1.70, 95% CI: 1.41-2.04), Asian Indian/Pakistani (OR = 1.37, 95% CI: 1.15-1.64), and PI men (OR = 1.90, 95% CI: 1.46-2.49) were more likely to present with metastatic PCa (P<0.001). In patients with localized PCa, Filipino men were less likely to receive definitive treatment (OR = 0.91; 95% CI: 0.84-0.97; P = 0.005). Most AAPI groups had lower rates of PCa death except for Hawaiian (hazard ratio = 1.52; 95% CI: 1.30-1.77; P<0.0001) and PI men (hazard ratio = 1.43; 95% CI: 1.12-1.82; P<0.0001). CONCLUSIONS: Compared with NHWs, AAPI groups were more likely to present with advanced PCa but had better cancer-specific survival. Conversely, Hawaiian and PI men were at greater risk for PCa-specific mortality. Given the different cancer profiles, our results show that there is a need for disaggregation of AAPI data.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged - administration & dosage
- Asian Americans - statistics & numerical data
- China - ethnology
- Humans - administration & dosage
- Japan - ethnology
- Korea - ethnology
- Logistic Models - administration & dosage
- Male - administration & dosage
- Middle Aged - administration & dosage
- Multivariate Analysis - administration & dosage
- Outcome Assessment, Health Care - methods, statistics & numerical data
- Philippines - ethnology
- Prostatic Neoplasms - diagnosis, ethnology, therapy
- SEER Program - statistics & numerical data
- Severity of Illness Index - administration & dosage
- Socioeconomic Factors - administration & dosage
- Survival Analysis - administration & dosage
- United States - administration & dosage
- Vietnam - ethnology
- Find related publications in this database (Keywords)
- Prostate cancer
- SEER
- Racial disparities
- Outcomes