Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Vidičević, S; Tošić, J; Stanojević, Ž; Isaković, A; Mitić, D; Ristić, D; Dekanski, D.
Standardized Olea europaea L. leaf extract exhibits protective activity in carbon tetrachloride-induced acute liver injury in rats: the insight into potential mechanisms.
Arch Physiol Biochem. 2020; 126(5): 399-407.
Doi: 10.1080/13813455.2018.1550095
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Ristic Dusica
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- The protective activity of dry olive leaf extract (DOLE) in carbon tetrachloride (CCl4)-induced liver damage and possible mechanisms involved in this protection were investigated in rats. Acute CCl4 intoxication resulted in a massive hepatic necrosis, in increased serum transaminases, and in a perturbation of oxidative stress parameters in liver tissue [malondyaldehide, glutathione (GSH), catalase]. CCl4 did not affect the expression of caspase-3 and cytochrome c as markers of apoptosis; however, CCl4 increased the AMP-activated protein kinase (AMPK) activity and the expression of autophagy-related protein LC3II and decreased the expression of p62 protein. The pre-treatment with DOLE significantly improved serum markers of liver damage, liver catalase activity, and GSH concentration, suggesting that antioxidative mechanism is responsible for hepatoprotection. Oral administration of DOLE did not influence LC3II conversion and p62 degradation in liver, but AMPK activity was significantly decreased, suggesting the energy balance perturbation as an additional potential mechanism of DOLE hepatoprotective effect.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals - administration & dosage
- Antioxidants - pharmacology
- Carbon Tetrachloride - toxicity
- Chemical and Drug Induced Liver Injury - drug therapy, etiology, metabolism, pathology
- Lipid Peroxidation - drug effects
- Male - administration & dosage
- Olea - chemistry
- Oxidative Stress - drug effects
- Plant Extracts - pharmacology
- Protective Agents - pharmacology
- Rats - administration & dosage
- Rats, Wistar - administration & dosage
- Find related publications in this database (Keywords)
- Liver toxicity
- hepatoprotection
- antioxidants
- apoptosis
- autophagy
- AMP-activated protein kinase