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Weis, J; Geiger, R; Kilo, J; Zimpfer, D.
Cormatrix® for vessel reconstruction in paediatric cardiac surgery-a word of caution.
Interact Cardiovasc Thorac Surg. 2022; 34(4): 597-603. Doi: 10.1093/icvts/ivab264 [OPEN ACCESS]
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Co-authors Med Uni Graz: Zimpfer Daniel
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Abstract:: OBJECTIVES: The aim of this retrospective study was to determine if Cormatrix® (CM) represents a safe alternative to conventional patch materials used in congenital heart surgery. METHODS: A total of 57 paediatric patients who underwent cardiac surgery using an Extracellular Matrix Bioscaffold (CM) were categorized into 4 groups according to the patch implant location. Patch-related complications and reintervention rates were analysed. A subgroup of 18 patients was subsequently compared to a matched group of 36 patients who underwent similar surgical procedures with autologous pericardium as patch material. RESULTS: No patient died during hospitalization. There were 2 late deaths, not related to the implanted CM patch. Fourteen (66.7%) out of 21 patients with arterial patch plasty developed progressive vessel/right ventricular outflow tract stenosis or aneurysm. All 3 patients with a valved CM conduit developed haemodynamically relevant valve stenosis or regurgitation. A total of 18 (31.5%) patients needed reintervention and 12 (21.1%) related to CM. Four (7%) patients needed surgical treatment with operative removal of the stenosis. Redo valve replacement was performed on 2 (3.5%) patients. Six (10.5%) patients required an interventional cardiology procedure at a median interval of 5 months from surgery. The subgroup analysis revealed a significantly lower patch-related reintervention rate in patients treated with autologous pericardium when compared to CM (P = 0.006). CONCLUSIONS: CM is safe for atrial and ventricular defect closure. The use of CM for arterial vessel reconstruction is associated with higher reintervention rates when compared to autologous pericardium.
Find related publications in this database (using NLM MeSH Indexing): Cardiac Surgical Procedures - adverse effects, methods; Child - administration & dosage; Heart Defects, Congenital - diagnostic imaging, surgery; Heart Ventricles - administration & dosage; Humans - administration & dosage; Pericardium - administration & dosage; Retrospective Studies - administration & dosage; Treatment Outcome - administration & dosage
Find related publications in this database (Keywords): Cormatrix(R); Small intestinal submucosa-extracellular matrix; Congenital heart defect Bioscaffold