Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
de, By, TMMH; Schoenrath, F; Veen, KM; Mohacsi, P; Stein, J; Alkhamees, KMM; Anastasiadis, K; Berhnardt, A; Beyersdorf, F; Caliskan, K; Reineke, D; Damman, K; Fiane, A; Gkouziouta, A; Gollmann-Tepeköylü, C; Finn, G; Hulman, M; Iacovoni, A; Loforte, A; Merkely, B; Musumeci, F; Němec, P; Netuka, I; Özbaran, M; Potapov, E; Pya, Y; Rábago, G; Ramjankhan, F; Reichenspurner, H; Saeed, D; Sandoval, E; Stockman, B; Vanderheyden, M; Tops, L; Wahlers, T; Zembala, M; Zimpfer, D; Carrel, T; Gummert, J; Meyns, B.
The European Registry for Patients with Mechanical Circulatory Support of the European Association for Cardio-Thoracic Surgery: third report.
Eur J Cardiothorac Surg. 2022;
Doi: 10.1093/ejcts/ezac032
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Zimpfer Daniel
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- OBJECTIVES: In the third report of the European Registry for Patients with Mechanical Circulatory Support of the European Association for Cardio-Thoracic Surgery, outcomes of patients receiving mechanical circulatory support are reviewed in relation to implant era. METHODS: Procedures in adult patients (January 2011-June 2020) were included. Patients from centres with <60% follow-ups completed were excluded. Outcomes were stratified into 3 eras (2011-2013, 2014-2017 and 2018-2020). Adverse event rates (AERs) were calculated and stratified into early phase (<3 months) and late phase (>3 months). Risk factors for death were explored using univariable Cox regression with a stepwise time-varying hazard ratio (<3 vs >3 months). RESULTS: In total, 4834 procedures in 4486 individual patients (72 hospitals) were included, with a median follow-up of 1.1 (interquartile range: 0.3-2.6) years. The annual number of implants (range: 346-600) did not significantly change (P = 0.41). Both Interagency Registry for Mechanically Assisted Circulatory Support class (classes 4-7: 23, 25 and 33%; P < 0.001) and in-hospital deaths (18.5, 17.2 and 11.2; P < 0.001) decreased significantly between eras. Overall, mortality, transplants and the probability of weaning were 55, 25 and 2% at 5 years after the implant, respectively. Major infections were mainly noted early after the implant occurred (AER<3 months: 1.44 vs AER>3 months: 0.45). Bilirubin and creatinine levels were significant risk factors in the early phase but not in the late phase after the implant. CONCLUSIONS: In its 10 years of existence, EUROMACS has become a point of reference enabling benchmarking and outcome monitoring. Patient characteristics and outcomes changed between implant eras. In addition, both occurrence of outcomes and risk factor weights are time dependent.
- Find related publications in this database (Keywords)
- Mechanical circulatory support
- Ventricular assist device
- Registry
- End-stage heart failure