Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Riebandt, J; Wiedemann, D; Sandner, S; Angleitner, P; Zuckermann, A; Schlöglhofer, T; Laufer, G; Zimpfer, D.
Impact of Less Invasive Left Ventricular Assist Device Implantation on Heart Transplant Outcomes.
Semin Thorac Cardiovasc Surg. 2022; 34(1): 148-156.
Doi: 10.1053/j.semtcvs.2021.02.001
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- Leading authors Med Uni Graz
- Zimpfer Daniel
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- Abstract:
- Left ventricular assist device implantation without sternotomy (LIS) may simplify heart transplantation (HTX) by avoiding adhesions and eliminating the need for a re-sternotomy. This study investigates the impact of LIS LVAD implantation on HTX outcomes. A retrospective comparison of 46 patients undergoing HTX between 07/13 and 06/19 after conventional LVAD implantation with a full sternotomy (FS) and LIS LVAD implantation (LIS: n = 27 patients, 59%; FS: n = 19 patients, 41%) was performed. Endpoints were perioperative data including blood product use, de-novo formation of donor specific antibodies (DSAs) and survival. Patient demographics (mean age FS: 60.3 ± 9.3 years vs LIS 58.0 ± 7.7 years, P = 0.313; male gender FS: 84% vs LIS: 82%, P = 1.000; urgent HTX FS: 16% vs LIS 18%, P = 1.000) were comparable between LIS and FS patients. The primary finding was a significantly higher risk to develop de novo donor specific antibodies (DSAs) after HTX in patients of the FS group (FS: 36% vs LIS: 4%; P = 0.006). LIS patients had a significant reduction of intraoperative packed red blood cells (PRBCs) use (LIS: 4 (IQR 2-7) Units vs FS: 7 (IQR 4-8) Units; P = 0.045). Other adverse events rates and in-hospital mortality (LIS: 7% vs FS 5%, P = 1.000) were comparable between both groups. LIS LVAD reduces formation of donor specific antibodies after HTX.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged - administration & dosage
- Heart Failure - diagnosis, surgery
- Heart Transplantation - adverse effects
- Heart-Assist Devices - adverse effects
- Humans - administration & dosage
- Male - administration & dosage
- Middle Aged - administration & dosage
- Retrospective Studies - administration & dosage
- Treatment Outcome - administration & dosage
- Find related publications in this database (Keywords)
- Mechanical circulatory support
- Heart transplantation
- Less invasive implantation strategies
- Outcomes
- Blood product use
- Sensitization