Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Marasco, S; Simon, AR; Tsui, S; Schramm, R; Eifert, S; Hagl, CM; Paç, M; Kervan, Ü; Fiane, AE; Wagner, FM; Garbade, J; Özbaran, M; Hayward, CS; Zimpfer, D; Schmitto, JD.
International experience using a durable, centrifugal-flow ventricular assist device for biventricular support.
J Heart Lung Transplant. 2020; 39(12): 1372-1379.
Doi: 10.1016/j.healun.2020.08.006
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Zimpfer Daniel
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- Abstract:
- BACKGROUND: Heart transplantation is limited by the scarcity of suitable donors. Patients with advanced biventricular failure may require biventricular support to provide optimal cardiac output and end-organ perfusion. We highlight the outcomes of using the HeartWare HVAD System (HVAD) in a biventricular configuration. METHODS: This retrospective study included patients implanted with HVAD as a biventricular assist device (BiVAD) between 2009 and 2017 at 12 participating centers. When used as a right ventricular assist device (VAD) (RVAD), the HVAD can be attached to the right ventricle (RV) or the right atrium (RA). Kaplan-Meier survival estimates were calculated comparing the 2 RVAD implant locations. Comparisons were also made between the timing of RVAD implantation (primary vs staged) on adverse event (AE) profiles and survival. RESULTS: Among the 93 patients who were implanted with a HVAD BiVAD, Kaplan-Meier survivals at 1-year and 2-year were 56% and 47%, respectively. Survival was independent of the location of the HVAD RVAD implant or whether there was an interval between left VAD and RVAD implantation. The most common AEs were bleeding (35.5%), infection (25.8%), and respiratory failure (20.4%). CONCLUSIONS: This study illustrated similar survival in patients receiving a primary or staged HVAD BiVAD implant at 1 year and 2 years. This study also established that the locations of the RVAD implant (RV or RA) result in similar AE profiles.
- Find related publications in this database (using NLM MeSH Indexing)
- Atrial Function, Right - physiology
- Follow-Up Studies - administration & dosage
- Global Health - administration & dosage
- Heart Atria - physiopathology
- Heart Failure - mortality, physiopathology, surgery
- Heart Ventricles - physiopathology
- Heart-Assist Devices - administration & dosage
- Humans - administration & dosage
- Retrospective Studies - administration & dosage
- Survival Rate - trends
- Treatment Outcome - administration & dosage
- Ventricular Function, Right - physiology
- Find related publications in this database (Keywords)
- biventricular assist device
- biventricular failure
- RVAD
- BiVAD
- HeartWare HVAD BiVAD