Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Schlöglhofer, T; Michalovics, P; Riebandt, J; Angleitner, P; Stoiber, M; Laufer, G; Schima, H; Wiedemann, D; Zimpfer, D; Moscato, F.
Left ventricular assist device driveline infections in three contemporary devices.
Artif Organs. 2021; 45(5): 464-472.
Doi: 10.1111/aor.13843
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- Co-authors Med Uni Graz
- Zimpfer Daniel
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- Abstract:
- Driveline infections (DLI) are common adverse events in left ventricular assist devices (LVADs), leading to severe complications and readmissions. The study aims to characterize risk factors for DLI readmission 2 years postimplant. This single-center study included 183 LVAD patients (43 HeartMate II [HMII], 29 HeartMate 3 [HM3], 111 HVAD) following hospital discharge between 2013 and 2017. Demographics, clinical parameters, and outcomes were retrospectively analyzed and 12.6% of patients were readmitted for DLI, 14.8% experienced DLI but were treated in the outpatient setting, and 72.7% had no DLI. Mean C-reactive protein (CRP), leukocytes and fibrinogen were higher in patients with DLI readmission (P < .02) than in outpatient DLI and patients without DLI, as early as 60 days before readmission. Freedom from DLI readmission was comparable for HMII and HVAD (98% vs. 87%; HR, 4.52; 95% CI, 0.58-35.02; P = .15) but significantly lower for HM3 (72%; HR, 10.82; 95% CI, 1.26-92.68; P = .03). DLI (HR, 1.001; 95% CI, 0.999-1.002; P = .16) or device type had no effect on mortality. DLI readmission remains a serious problem following LVAD implantation, where CRP, leukocytes, and fibrinogen might serve as risk factors already 60 days before. HM3 patients had a higher risk for DLI readmissions compared to HVAD or HMII, possibly because of device-specific driveline differences.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult - administration & dosage
- Aged - administration & dosage
- Biomarkers - blood
- C-Reactive Protein - analysis
- Female - administration & dosage
- Fibrinogen - analysis
- Follow-Up Studies - administration & dosage
- Heart Failure - surgery
- Heart-Assist Devices - adverse effects
- Humans - administration & dosage
- Leukocyte Count - administration & dosage
- Male - administration & dosage
- Middle Aged - administration & dosage
- Patient Readmission - statistics & numerical data
- Prosthesis-Related Infections - blood, diagnosis, epidemiology, therapy
- Retrospective Studies - administration & dosage
- Risk Assessment - methods, statistics & numerical data
- Risk Factors - administration & dosage
- Find related publications in this database (Keywords)
- driveline infection
- mechanical circulatory support
- readmission
- risk factors
- ventricular assist device