Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Irschik, S; Stelzl, S; Golej, J; Schlager, G; Zimpfer, D; Herbst, C; Michel-Behnke, I; Kitzmüller, E; Base, E; Hermon, M.
Direct postoperative protein S100B and NIRS monitoring in infants after pediatric cardiac surgery enrich early mortality assessment at the PICU.
Heart Lung. 2020; 49(6):731-736
Doi: 10.1016/j.hrtlng.2020.08.014
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Zimpfer Daniel
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- Abstract:
- BACKGROUND: Neuromonitoring using plasmatic biomarkers such as S100B and near-infrared spectroscopy (NIRS) represents a standard procedure for detecting cerebral damage after cardiac surgery. Their use in pediatric clinical assessment, however, is negligible. OBJECTIVES: The goal of this study was to evaluate the predictive role of S100B levels and cerebral oxygenation in postoperative pediatric cardiac patients for survival and potential cerebral injuries. METHODS: A retrospective cohort study of infants after cardiac surgery. Primary outcome was survival until discharge. Intra/postoperative vital signs and laboratory data were measured and statistically analyzed. RESULTS: Seven out of 226 infants were non-survivors. Non-survivors had significantly lower cerebral saturation than survivors, as well as elevated S100B values at admission, associated with lower arterial pressure and higher serum lactate levels. CONCLUSION: Although significant differences of S100B and crO2 values between survivors and non-survivors were found, no critical thresholds could be established from the data. Nevertheless, changes from the norm in these parameters should raise awareness for critical clinical development.
- Find related publications in this database (using NLM MeSH Indexing)
- Cardiac Surgical Procedures - adverse effects
- Child - administration & dosage
- Humans - administration & dosage
- Infant - administration & dosage
- Intensive Care Units, Pediatric - administration & dosage
- Oxygen - administration & dosage
- Retrospective Studies - administration & dosage
- S100 Calcium Binding Protein beta Subunit - administration & dosage
- Spectroscopy, Near-Infrared - administration & dosage
- Find related publications in this database (Keywords)
- Cardiac surgery
- S100B
- NIRS
- Survival
- Neuromonitoring