Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Grabska, J; Schlöglhofer, T; Gross, C; Maw, M; Dimitrov, K; Wiedemann, D; Zimpfer, D; Schima, H; Moscato, F.
Early Detection of Pump Thrombosis in Patients With Left Ventricular Assist Device.
ASAIO J. 2020; 66(4):348-354
Doi: 10.1097/MAT.0000000000001015
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Zimpfer Daniel
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Pump thrombosis (PT) is a serious adverse event in patients receiving left ventricular assist devices (LVAD). The study aims to determine whether pump parameters and clinical data may enable early detection of PT. This retrospective study included 88 patients who received an LVAD between 2012 and 2015 among which those with intra-PT were identified. In a propensity score-matched control group observation, time periods were matched with time before thrombosis. International normalized ratio (INR) time in therapeutic range (TTR) and lactate dehydrogenase (LDH) were analyzed for 60 days preceding PT. Furthermore, pump data (power, flow, and speed) in HeartWare ventricular assist devices (HVAD) patients were analyzed 7 days before PT using a mixed-design analysis of variance to investigate temporal changes in pump data. Pump thrombosis occurred in 15 patients (13 males, age 58 ± 10 years, 7 HeartMate II and 8 HVAD). International normalized ratio therapeutic range (2.0-3.0) and acetylsalicylic acid daily doses (100-200 mg) were similar for both groups, but patients with PT had lower TTR (36% vs. 65%; p = 0.025). No significant difference in LVAD power between groups was seen at baseline (p = 0.31), and power did not change in the control group over time (p > 0.99). Lactate dehydrogenase increased already 1 week prior PT and power from 4.4 ± 0.8 W at baseline to 4.9 ± 0.8 W (p = 0.007) 2 days before readmission and to 6.5 ± 1.8 W (p = 0.015) at readmission. Pump thrombosis is associated with a lower percentage of INR TTR and elevated LDH before the event. A better monitoring of pump parameters would enable PT detection already up to 2 days in advance.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged - administration & dosage
- Early Diagnosis - administration & dosage
- Female - administration & dosage
- Heart Failure - therapy
- Heart-Assist Devices - adverse effects
- Humans - administration & dosage
- L-Lactate Dehydrogenase - blood
- Male - administration & dosage
- Middle Aged - administration & dosage
- Retrospective Studies - administration & dosage
- Thrombosis - diagnosis, etiology
- Find related publications in this database (Keywords)
- ventricular assist device
- pump thrombus
- early detection
- log files
- anticoagulation quality