Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Holfeld, J; Zimpfer, D; Albrecht-Schgoer, K; Stojadinovic, A; Paulus, P; Dumfarth, J; Thomas, A; Lobenwein, D; Tepeköylü, C; Rosenhek, R; Schaden, W; Kirchmair, R; Aharinejad, S; Grimm, M.
Epicardial shock-wave therapy improves ventricular function in a porcine model of ischaemic heart disease.
J Tissue Eng Regen Med. 2016; 10(12):1057-1064
Doi: 10.1002/term.1890
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Zimpfer Daniel
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- Abstract:
- Previously we have shown that epicardial shock-wave therapy improves left ventricular ejection fraction (LVEF) in a rat model of myocardial infarction. In the present experiments we aimed to address the safety and efficacy of epicardial shock-wave therapy in a preclinical large animal model and to further evaluate mechanisms of action of this novel therapy. Four weeks after left anterior descending (LAD) artery ligation in pigs, the animals underwent re-thoracotomy with (shock-wave group, n = 6) or without (control group, n = 5) epicardial shock waves (300 impulses at 0.38 mJ/mm2 ) applied to the infarcted anterior wall. Efficacy endpoints were improvement of LVEF and induction of angiogenesis 6 weeks after shock-wave therapy. Safety endpoints were haemodynamic stability during treatment and myocardial damage. Four weeks after LAD ligation, LVEF decreased in both the shock-wave (43 ± 3%, p < 0.001) and control (41 ± 4%, p = 0.012) groups. LVEF markedly improved in shock-wave animals 6 weeks after treatment (62 ± 9%, p = 0.006); no improvement was observed in controls (41 ± 4%, p = 0.36), yielding a significant difference. Quantitative histology revealed significant angiogenesis 6 weeks after treatment (controls 2 ± 0.4 arterioles/high-power field vs treatment group 9 ± 3; p = 0.004). No acute or chronic adverse effects were observed. As a potential mechanism of action in vitro experiments showed stimulation of VEGF receptors after shock-wave treatment in human coronary artery endothelial cells. Epicardial shock-wave treatment in a large animal model of ischaemic heart failure exerted a positive effect on LVEF improvement and did not show any adverse effects. Angiogenesis was induced by stimulation of VEGF receptors. Copyright © 2014 John Wiley & Sons, Ltd.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals - administration & dosage
- Disease Models, Animal - administration & dosage
- Female - administration & dosage
- High-Energy Shock Waves - administration & dosage
- Humans - administration & dosage
- Myocardial Ischemia - physiopathology, therapy
- Neovascularization, Physiologic - administration & dosage
- Pericardium - administration & dosage
- Swine - administration & dosage
- Ultrasonic Therapy - methods
- Ventricular Function, Left - administration & dosage
- Find related publications in this database (Keywords)
- shockwave therapy
- myocardial infarction
- left ventricular ejection fraction
- angiogenesis
- endothelial cells
- vascular endothelial growth factor