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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Sandner, SE; Zimpfer, D; Zrunek, P; Steinlechner, B; Rajek, A; Schima, H; Wolner, E; Wieselthaler, GM.
Low molecular weight heparin as an alternative to unfractionated heparin in the immediate postoperative period after left ventricular assist device implantation.
Artif Organs. 2008; 32(10):819-22
Doi: 10.1111/j.1525-1594.2008.00634.x
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Zimpfer Daniel
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- Abstract:
- We present a regimen for anticoagulation in the immediate postoperative period after left ventricular assist device (LVAD) implantation using low molecular weight heparin (LMWH) as an alternative to unfractionated heparin. Between May and September 2007, eight consecutive patients undergoing LVAD implantation for advanced heart failure received the LMWH nadroparin. Nadroparin was given twice daily to achieve anti-Factor Xa activity target peak levels of 0.4 +/- 0.1 U/mL. The antiplatelet therapy consisted of aspirin (100 mg/day) and dipyridamole (3 x 75 mg/day). One patient underwent heart transplantation, three patients died, and four patients continued to receive device support. The median duration of support was 78 days (range, 46 to 174). No major bleeding was observed; minor bleeding occurred in three patients. In two patients, pump thrombosis was suspected. There were two ischemic and no hemorrhagic strokes. The use of LMWH may provide a new anticoagulation treatment option in the immediate postoperative period after LVAD implantation.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged - administration & dosage
- Anticoagulants - administration & dosage, therapeutic use
- Aspirin - administration & dosage
- Dipyridamole - administration & dosage
- Heart Failure - surgery, therapy
- Heart-Assist Devices - administration & dosage
- Heparin - chemistry
- Heparin, Low-Molecular-Weight - administration & dosage, therapeutic use
- Humans - administration & dosage
- Middle Aged - administration & dosage
- Nadroparin - administration & dosage, therapeutic use
- Outcome Assessment, Health Care - administration & dosage
- Postoperative Period - administration & dosage
- Prostheses and Implants - adverse effects
- Thrombosis - prevention & control
- Find related publications in this database (Keywords)
- Anticoagulation
- Bridge to transplantation
- Left ventricular assist device
- Low molecular weight heparin
- Unfractionated heparin