Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Dworschak, M; Lassnigg, A; Tenze, G; Zimpfer, D; Czerny, M; Grimm, M; Schmid, R; Grubhofer, G.
Perfusion temperature during cardiopulmonary bypass does not affect serum S-100beta release.
Thorac Cardiovasc Surg. 2004; 52(1):29-33
Doi: 10.1055/s-2004-817799
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Zimpfer Daniel
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- Abstract:
- BACKGROUND: The potentially harmful effects of normothermia on neurological outcome during cardiopulmonary bypass (CPB) are controversial. METHODS: In this study, we compared the early and late release patterns of S-100beta, a marker of cerebral injury, after normothermic and moderately hypothermic CPB. Forty-eight patients undergoing coronary artery bypass grafting were randomly assigned to either the normothermia (37 degrees C) or the hypothermia (32 degrees C) group. Serum S-100beta levels were measured until 24 h after CPB. Neurological examination was performed before and after surgery. RESULTS: With the exception of intraoperative blood glucose levels, there were no differences between groups. This also applied to peak S-100beta values (Gr-N: 3.5 +/- 1.9 microg/l; Gr-H: 3.5 +/- 3.4 microg/l) and values after 24 h (Gr-N: 0.32 +/- 0.16 microg/l; Gr-H: 0.35 +/- 0.28 microg/l). CONCLUSIONS: The similar pattern of S-100beta release without evident neurological complications in the normothermia group does not suggest an increase in cerebral injury during normothermic CPB.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged - administration & dosage
- Biomarkers - blood
- Blood Glucose - metabolism
- Cardiopulmonary Bypass - administration & dosage
- Coronary Artery Bypass - administration & dosage
- Coronary Disease - metabolism, surgery
- Creatine Kinase - blood
- Creatine Kinase, MB Form - administration & dosage
- Hemoglobins - metabolism
- Humans - administration & dosage
- Hypothermia, Induced - administration & dosage
- Isoenzymes - blood
- Length of Stay - administration & dosage
- Middle Aged - administration & dosage
- Nerve Growth Factors - administration & dosage
- Perfusion - administration & dosage
- Postoperative Complications - etiology, mortality
- Prospective Studies - administration & dosage
- S100 Calcium Binding Protein beta Subunit - administration & dosage
- S100 Proteins - metabolism
- Statistics as Topic - administration & dosage
- Survival Analysis - administration & dosage
- Time Factors - administration & dosage
- Treatment Outcome - administration & dosage
- Find related publications in this database (Keywords)
- cardiopulmonary bypass
- normothermia
- brain injury
- biochemical markers
- S-100 beta