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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Naiyanetr, P; Moscato, F; Vollkron, M; Zimpfer, D; Wieselthaler, G; Schima, H.
Continuous assessment of cardiac function during rotary blood pump support: a contractility index derived from pump flow.
J Heart Lung Transplant. 2010; 29(1):37-44
Doi: 10.1016/j.healun.2009.05.032
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Zimpfer Daniel
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- Abstract:
- BACKGROUND: The clinical application of rotary blood pumps (RBPs) for bridge-to-recovery and destination therapy has focused interest on the remaining contractile function of the heart and its course. This study reports a method to determine contractility that uses readily measured variables of the RBP. METHOD: The proposed index (I(Q)) is defined as the slope of a linear regression between the maximum derivative of the pump flow and its peak-to-peak value. I(Q) was compared with the maximal derivative of ventricular pressure (dP/dt(max)) vs end-diastolic volume (EDV) and the pre-load-recruitable stroke work. All indices were evaluated using computer simulations and animal experiments. For in vivo studies, a MicroMed-DeBakey ventricular assist device (VAD) was implanted in 7 healthy sheep. Ventricular contractility was examined under normal conditions and after pharmacologic intervention. For the computer simulation, variations of ventricular contractility, ventricular pre-load and after-load, and pump speeds were studied. RESULTS: In vivo and computer simulations showed the I(Q) index to be sensitive to changes of cardiac contractility, similar to other classic indices. For reduced cardiac contractility, it decreased to 9.3 +/- 3.9 (s(-1)) vs 15.3 +/- 4.0 (s(-1)) in the control condition (in vivo experiments). The I(Q) index was only marginally influenced by pre-load and after-load changes: a variation of 7.0% +/- 8.9% and 1.3% +/- 7.1%, respectively, was observed in computer simulations. CONCLUSIONS: The I(Q) index, which can be derived from pump data only, is a useful parameter for continuous monitoring of the cardiac contractility in patients with RBP support.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals - administration & dosage
- Blood Circulation - physiology
- Computer Simulation - administration & dosage
- Heart - physiology
- Heart Rate - physiology
- Heart-Assist Devices - administration & dosage
- Linear Models - administration & dosage
- Models, Animal - administration & dosage
- Models, Cardiovascular - administration & dosage
- Myocardial Contraction - physiology
- Sheep - administration & dosage
- Find related publications in this database (Keywords)
- rotary blood pump
- contractility
- cardiac function
- left ventricular assist device
- pump flow
- index