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Enko, D; Meinitzer, A; Zelzer, S; Herrmann, M; Artinger, K; Rosenkranz, AR; Zitta, S.
Vitamin D metabolism in living kidney donors before and after organ donation.
Clin Chem Lab Med. 2022; 60(8):1218-1224 Doi: 10.1515/cclm-2022-0148
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Leading authors Med Uni Graz: Enko Dietmar; Meinitzer Andreas
Co-authors Med Uni Graz: Artinger Katharina; Herrmann Markus; Rosenkranz Alexander; Zelzer Sieglinde; Zitta Sabine
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Abstract:: OBJECTIVES: Living kidney donors provide a unique setting to study functional and metabolic consequences after organ donation. Since the lack of data of the homoeostasis of numerous vitamin D metabolites in these healthy subjects, the aim of this study was to assess the vitamin D metabolism before and after kidney donation. METHODS: We investigated the 25-dihydroxyvitamin D₂ (25[OH]D₂), 25-dihydroxyvitamin D₃ (25[OH]D₃), 1,25-dihydroxyvitamin D₃ (1,25[OH]₂D₃), 24,25-dihydroxyvitamin D₃ (24,25[OH]₂D₃), 25,26-dihydroxyvitamin D₃ (25,26[OH]₂D₃), and the native vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol) in a well characterized study cohort of 32 healthy living kidney donors before and after organ donation. RESULTS: Thirty-two healthy subjects after kidney donation had significantly lower median (interquartile range) 1,25(OH)₂D₃ serum concentrations (88.6 [62.6-118.8] vs. 138.0 [102.6-152.4] pmol/L, p<0.001) and significantly higher median 25(OH)D₂ serum levels (1.80 [1.19-2.19] vs. 1.11 [0.74-1.59] nmol/L, p=0.019) than before donation. Similar serum concentrations of 25(OH)D₃ and 25,26(OH)₂D₃ were observed before and after donation. The 24,25(OH)₂D₃ blood levels distinctly decreased after organ donation (4.1 [2.3-5.3] vs. 5.3 [2.2-6.9] nmol/L, p=0.153). Native vitamin D2 (0.10 [0.08-0.14] vs. 0.08 [0.06-0.12] nmol/L, p=0.275) was slightly increased and vitamin D3 (1.6 [0.6-7.2] vs. 2.5 [0.9-8.6] nmol/L, p=0.957) decreased after kidney donation. CONCLUSIONS: Living kidney donors were found with decreased 1,25(OH)₂D₃ and 24,25(OH)₂D₃, increased 25(OH)D₂ and consistent 25(OH)D₃ and 25,26(OH)₂D₃ serum concentrations after organ donation. The current study advances the understanding on vitamin D metabolism suggesting that altered hydroxylase-activities after donation is accompanied by compensatory elevated dietary-related 25(OH)D₂ blood concentrations.
Find related publications in this database (using NLM MeSH Indexing): Calcifediol - administration & dosage; Cholecalciferol - administration & dosage; Ergocalciferols - administration & dosage; Humans - administration & dosage; Kidney - administration & dosage; Kidney Transplantation - administration & dosage; Tissue and Organ Procurement - administration & dosage; Vitamin D - administration & dosage
Find related publications in this database (Keywords): living kidney donors; metabolism; nephrectomy; vitamin D