Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Enko, D; Meinitzer, A; Zelzer, S; Herrmann, M; Artinger, K; Rosenkranz, AR; Zitta, S.
Vitamin D metabolism in living kidney donors before and after organ donation.
Clin Chem Lab Med. 2022; 60(8):1218-1224
Doi: 10.1515/cclm-2022-0148
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Enko Dietmar
- Meinitzer Andreas
- Co-Autor*innen der Med Uni Graz
- Artinger Katharina
- Herrmann Markus
- Rosenkranz Alexander
- Zelzer Sieglinde
- Zitta Sabine
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- Abstract:
- OBJECTIVES: Living kidney donors provide a unique setting to study functional and metabolic consequences after organ donation. Since the lack of data of the homoeostasis of numerous vitamin D metabolites in these healthy subjects, the aim of this study was to assess the vitamin D metabolism before and after kidney donation. METHODS: We investigated the 25-dihydroxyvitamin D2 (25[OH]D2), 25-dihydroxyvitamin D3 (25[OH]D3), 1,25-dihydroxyvitamin D3 (1,25[OH]2D3), 24,25-dihydroxyvitamin D3 (24,25[OH]2D3), 25,26-dihydroxyvitamin D3 (25,26[OH]2D3), and the native vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol) in a well characterized study cohort of 32 healthy living kidney donors before and after organ donation. RESULTS: Thirty-two healthy subjects after kidney donation had significantly lower median (interquartile range) 1,25(OH)2D3 serum concentrations (88.6 [62.6-118.8] vs. 138.0 [102.6-152.4] pmol/L, p<0.001) and significantly higher median 25(OH)D2 serum levels (1.80 [1.19-2.19] vs. 1.11 [0.74-1.59] nmol/L, p=0.019) than before donation. Similar serum concentrations of 25(OH)D3 and 25,26(OH)2D3 were observed before and after donation. The 24,25(OH)2D3 blood levels distinctly decreased after organ donation (4.1 [2.3-5.3] vs. 5.3 [2.2-6.9] nmol/L, p=0.153). Native vitamin D2 (0.10 [0.08-0.14] vs. 0.08 [0.06-0.12] nmol/L, p=0.275) was slightly increased and vitamin D3 (1.6 [0.6-7.2] vs. 2.5 [0.9-8.6] nmol/L, p=0.957) decreased after kidney donation. CONCLUSIONS: Living kidney donors were found with decreased 1,25(OH)2D3 and 24,25(OH)2D3, increased 25(OH)D2 and consistent 25(OH)D3 and 25,26(OH)2D3 serum concentrations after organ donation. The current study advances the understanding on vitamin D metabolism suggesting that altered hydroxylase-activities after donation is accompanied by compensatory elevated dietary-related 25(OH)D2 blood concentrations.
- Find related publications in this database (using NLM MeSH Indexing)
- Calcifediol - administration & dosage
- Cholecalciferol - administration & dosage
- Ergocalciferols - administration & dosage
- Humans - administration & dosage
- Kidney - administration & dosage
- Kidney Transplantation - administration & dosage
- Tissue and Organ Procurement - administration & dosage
- Vitamin D - administration & dosage
- Find related publications in this database (Keywords)
- living kidney donors
- metabolism
- nephrectomy
- vitamin D