Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Taucher, E; Mykoliuk, I; Fediuk, M; Smolle-Juettner, FM.
Autophagy, Oxidative Stress and Cancer Development.
CANCERS. 2022; 14(7):
Doi: 10.3390/cancers14071637
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- Führende Autor*innen der Med Uni Graz
- Taucher Elisabeth
- Co-Autor*innen der Med Uni Graz
- Fediuk Melanie
- Mykoliuk Iurii
- Smolle-Juettner Freyja-Maria
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- Abstract:
- Autophagy is an important cellular repair mechanism, aiming at sequestering misfolded and dysfunctional proteins and damaged cell organelles. Dysfunctions in the autophagy process have been linked to several diseases, like infectious and neurodegenerative diseases, type II diabetes mellitus and cancer. Living organisms are constantly subjected to some degree of oxidative stress, mainly induced by reactive oxygen and nitrogen species. It has been shown that autophagy is readily induced by reactive oxygen species (ROS) upon nutrient deprivation. In recent years, research has increasingly focused on outlining novel therapeutic targets related to the autophagy process. With this review of the literature, we want to give an overview about the link between autophagy, oxidative stress and carcinogenesis.
- Find related publications in this database (Keywords)
- oxidative stress
- autophagy
- cancer