Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Feigl, S; Obermayer-Pietsch, B; Klaritsch, P; Pregartner, G; Herzog, SA; Lerchbaum, E; Trummer, C; Pilz, S; Kollmann, M.
Impact of Thyroid Function on Pregnancy and Neonatal Outcome in Women with and without PCOS.
Biomedicines. 2022; 10(4):
Doi: 10.3390/biomedicines10040750
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Feigl Sarah
- Kollmann Martina
- Co-Autor*innen der Med Uni Graz
- Herzog Sereina Annik
- Klaritsch Philipp
- Lerchbaum Elisabeth
- Obermayer-Pietsch Barbara
- Pilz Stefan
- Pregartner Gudrun
- Trummer Christian
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- BACKGROUND: Women with polycystic ovary syndrome (PCOS) are more prone to autoimmune thyroiditis, and both disorders lead to subfertility and pregnancy-related complications. The aim of this study was to investigate whether mothers with and without PCOS and their offspring have comparable thyroid parameters at term and how thyroid parameters are associated with perinatal outcome in this population. METHODS: This cross-sectional observational study was performed in a single academic tertiary hospital in Austria. Seventy-nine pregnant women with PCOS and 354 pregnant women without PCOS were included. Blood samples were taken from the mother and cord blood at birth. Primary outcome parameters were maternal and neonatal thyroid parameters at delivery. Secondary outcome parameters were the composite complication rate per woman and per neonate. RESULTS: Thyroid dysfunction was more prevalent among PCOS women (p < 0.001). At time of birth, free triiodothyronine (fT3) levels were significantly lower in PCOS than in non-PCOS women (p = 0.005). PCOS women and their neonates had significantly higher thyreoperoxidase antibody (TPO-AB) levels (p = 0.001). Women with elevated TPO-AB had a significantly higher prevalence of hypothyroidism (p < 0.001). There was a significant positive correlation between maternal and neonatal free thyroxine, fT3 and TPO-AB levels. There were no significant differences in thyroid parameters between women or neonates with or without complications. CONCLUSIONS: Our results demonstrate a higher prevalence of thyroid dysfunction and autoimmunity in PCOS women, supporting a common etiology of both disorders. We were not able to show an association between complication rate and thyroid parameters.
- Find related publications in this database (Keywords)
- polycystic ovary syndrome (PCOS)
- thyroid disorders in pregnancy
- autoimmune thyroid disease