Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Sperl, D; Lang, P; Benesch, M; Bainschab, A; Urban, C; Wilfing, R; Feuchtinger, T; Döring, M; Seitz, C; Strenger, V; Lackner, H; Seidel, MG; Perwein, T; Handgretinger, R; Sipurzynski, S; Rosskopf, K; Schwinger, W.
Immunological recovery following HLA-matched CD3+ TCR αß+/CD19+ depleted hematopoietic stem cell transplantation in children.
Pediatr Transplant. 2022; 26(5):e14285
Doi: 10.1111/petr.14285
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Schwinger Wolfgang
- Sperl Daniela Ingrid
- Co-Autor*innen der Med Uni Graz
- Bainschab Antonia
- Benesch Martin
- Lackner Herwig
- Perwein Thomas
- Rosskopf Konrad
- Seidel Markus
- Sipurzynski Sabine
- Strenger Volker
- Urban Ernst-Christian
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- Abstract:
- BACKGROUND: Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative option for children with both malignant and nonmalignant diseases. T-cell depletion techniques may result in reduced transplant-related mortality compared with unmanipulated grafts due to a lower incidence of GvHD. METHODS: Immune recovery and outcome were analyzed in a cohort of 23 patients with malignant and nonmalignant diseases who received CD3+TCRαβ+ T- and B-cell-depleted allografts from matched donors after reduced-intensity or myeloablative conditioning. The median number of CD34+, CD3+TCRαβ+, and CD19+B-cells infused was 12.7 × 106 /kg, 16.8 × 103 /kg, and 96 × 103 /kg bodyweight. RESULTS: With a median follow-up of 36 (range 1-73) months, overall survival and disease-free survival at 3 years were 65.2% and 60.8%. Eight patients died, six due to the underlying disease and two of extended visceral cGvHD. Immune reconstitution, disease-free, and overall survivals were similar compared with a historical cohort of 23 patients transplanted with matched unmanipulated bone marrow. A significant lower rate of higher grade (III-IV) aGvHD was observed in the manipulated HSCT group (8.7% vs. 26%; p = 0.001), whereas the incidence of cGvHD was equal. CONCLUSIONS: Our data suggest that this graft manipulation strategy could be a safe and effective alternative to conventional HSCT techniques in matched donors.
- Find related publications in this database (using NLM MeSH Indexing)
- Antigens, CD19 - administration & dosage
- Child - administration & dosage
- Graft vs Host Disease - administration & dosage
- Hematopoietic Stem Cell Transplantation - methods
- Humans - administration & dosage
- Lymphocyte Depletion - administration & dosage
- Receptors, Antigen, T-Cell, alpha-beta - administration & dosage
- Transplantation Conditioning - methods
- Find related publications in this database (Keywords)
- children
- hematopoetic stem cell transplantation
- immune reconstitution
- t-cell depletion