Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Direkt zur Navigaton springen.
Direkt zum Inhalt springen.

Navigation/Suche

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Végh, D; Somogyi, A; Bányai, D; Lakatos, M; Balogh, M; Al-Khrasani, M; Fürst, S; Vizi, ES; Hermann, P.
Effects of articaine on [³H]noradrenaline release from cortical and spinal cord slices prepared from normal and streptozotocin-induced diabetic rats and compared to lidocaine.
Brain Res Bull. 2017; 135:157-162 Doi: 10.1016/j.brainresbull.2017.10.011
Web of Science PubMed FullText FullText_MUG

Führende Autor*innen der Med Uni Graz: Vegh Daniel Csaba
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: Since a significant proportion of diabetic patients have clinical or subclinical neuropathy, there may be concerns about the use of local anaesthetics. The present study was designed to determine and compare the effects of articaine, a widely used anaesthetic in dental practice, and lidocaine on the resting and axonal stimulation-evoked release of [³H]noradrenaline ([³H]NA) in prefrontal cortex slices and the release of [³H]NA in spinal cord slices prepared from non-diabetic and streptozocin (STZ)-induced diabetic (glucose level=22.03±2.31mmol/l) rats. The peak of allodynia was achieved 9 weeks after STZ-treatment. Articaine and lidocaine inhibited the stimulation-evoked release in a concentration-dependent manner and increased the resting release by two to six times. These effects indicate an inhibitory action of these anaesthetics on Na⁺- and K⁺-channels. There was no difference in clinically important nerve conduction between non-diabetic and diabetic rats, as measured by the release of transmitter in response to axonal stimulation. The uptake and resting release of NA was significantly higher in the brain slices prepared from diabetic rats, but there were no differences in the spinal cord. For the adverse effects, the effects of articaine on K⁺ channels (resting release) are more pronounced compared to lidocaine. In this respect, articaine has a thiophene ring with high lipid solubility, which may present potential risks for some patients.
Find related publications in this database (using NLM MeSH Indexing): Adrenergic Neurons - drug effects; Anesthesia, Local - administration & dosage; Animals - administration & dosage; Axons - drug effects; Brain - drug effects; Carticaine - metabolism, pharmacology; Diabetes Mellitus, Experimental - chemically induced, metabolism; Lidocaine - metabolism, pharmacology; Male - administration & dosage; Neural Conduction - drug effects; Norepinephrine - metabolism, physiology; Olfactory Cortex - cytology; Rats - administration & dosage; Rats, Wistar - administration & dosage; Spinal Cord - cytology; Streptozocin - pharmacology
Find related publications in this database (Keywords): Articaine; Lidocaine; Noradrenaline release; Diabetic rats; Cortex; Spinal cord