Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Huber, C; Fuchs, D; Niederwieser, D; Hausen, A; Reibnegger, G; Nilsson, K; Wachter, H.
Neopterin, a new biochemical marker for clinical assessment of cell-mediated immune response
KLIN WOCHENSCHR. 1984; 62(3): 103-113. Doi: 10.1007/BF01738700
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Co-Autor*innen der Med Uni Graz: Reibnegger Gilbert
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Abstract:: Activated T-lymphocytes represent crucial effector cells. They are pathogenetically involved into various disease states such as allograft rejection or viral infection. So far their assessment is laborious and rarely possible in clinical routine. In this review article we present the compount neopterin as a new biochemical marker for the in vivo and in vitro detection of activated T-lymphocytes. Our main finding was that in vitro as well as in vivo stimulation of T-lymphocytes with foreign and chemically or virally modified autologous cells in invariably associated with increased neopterin production. It thus appeared that neopterin might represent a potential marker for biochemical monitoring of diseases caused by or associated with T-lymphocyte activation. Our clinical experience with neopterin determination in allograft rejection and in infectious or autoimmune states strongly support this view. We conclude that evaluation of neopterin represents a useful and simple tool for the biochemical monitoring of immunological and/or malignant states.
Find related publications in this database (using NLM MeSH Indexing): Adolescent -; Adult -; Aged -; Biopterin - analogs and derivatives; Female - analogs and derivatives; Humans - analogs and derivatives; Immune System Diseases - immunology; Immunity, Cellular - immunology; Male - immunology; Middle Aged - immunology; Neopterin - immunology; Pteridines - biosynthesis; T-Lymphocytes - immunology