Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kremer, N; Rako, Z; Douschan, P; Gall, H; Ghofrani, HA; Grimminger, F; Guth, S; Naeije, R; Rieth, A; Schulz, R; Seeger, W; Tedford, RJ; Vadász, I; Vanderpool, R; Wiedenroth, CB; Richter, MJ; Tello, K.
Unmasking right ventricular-arterial uncoupling during fluid challenge in pulmonary hypertension.
J Heart Lung Transplant. 2022; 41(3):345-355
Doi: 10.1016/j.healun.2021.11.019
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Douschan Philipp
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- Abstract:
- BACKGROUND: Patients with pulmonary hypertension (PH) frequently show preserved right ventricular (RV) function at rest. However, volume challenge may uncover pending RV dysfunction. We aimed to assess the physiological and prognostic impact of RV-pulmonary arterial (RV-PA) uncoupling during volume challenge in patients with precapillary PH. METHODS: We prospectively assessed 32 patients with PH (pulmonary arterial hypertension, n = 27; inoperable chronic thromboembolic disease, n = 5) and 4 controls using invasive pressure-volume (PV) catheterization. PV loops were recorded during preload reduction (balloon occlusion of inferior vena cava; baseline) and acute volume loading (200 ml saline in 20 s). Contractility (multi-beat end-systolic elastance [Ees]), arterial elastance (Ea), and RV-PA coupling (Ees/Ea) were obtained at baseline and at maximum volume loading (MVL). RESULTS: Median [interquartile range] time to MVL was 19 [18-22] s. Ees/Ea significantly declined from baseline (0.89 [0.69-1.23]) to MVL (0.16 [0.12-0.34]; p < 0.001) in patients with PH but remained stable in controls (baseline: 1.08 [0.94-1.80]; MVL: 1.01 [0.80-2.49]; p = 0.715). The same pattern was observed for Ees, while Ea remained unchanged. The percent decline of RV-PA coupling (ΔEes/Ea) during fluid challenge was significantly associated with pulmonary resting hemodynamics, RV ejection fraction (RVEF), and RV end-diastolic volume. Kaplan-Meier analysis revealed that patients with PH who had a smaller ΔEes/Ea (<-65%) had a significantly better prognosis (log-rank p = 0.0389). In multivariate Cox regression analysis, clinical worsening was predicted by ΔEes/Ea (hazard ratio: 0.96 [95% confidence interval: 0.93-1.00]) and RVEF (hazard ratio: 0.95 [95% confidence interval: 0.92-0.98]). CONCLUSIONS: Assessment of PV loops during fluid challenge uncovers exhausted RV coupling reserve with severely reduced contractility in PH. RV-PA uncoupling during volume challenge can be predicted by pulmonary resting hemodynamics and RVEF. RV-PA uncoupling during fluid challenge and RVEF (as a noninvasive correlate) are predictors of clinical worsening. CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifier: NCT03403868 (January 19, 2018).
- Find related publications in this database (using NLM MeSH Indexing)
- Fluid Therapy - administration & dosage
- Heart Ventricles - physiopathology
- Humans - administration & dosage
- Hypertension, Pulmonary - physiopathology
- Prospective Studies - administration & dosage
- Pulmonary Artery - physiopathology
- Ventricular Dysfunction, Right - physiopathology
- Find related publications in this database (Keywords)
- Right ventricle
- Pressure-volume relationship
- Pulmonary hypertension
- Systolic function
- Right ventricular-pulmonary arterial coupling