Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Niederwieser, D; Albert, E; Fuchs, D; Hausen, A; Margreiter, R; Reibnegger, G; Schönitzer, D; Troppmair, J; Wachter, H; Huber, C.
Neopterin release in human mixed lymphocyte culture: requirement of HLA-DR disparity.
Immunol Lett. 1985; 11(2):95-99 Doi: 10.1016/0165-2478(85)90149-X
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Co-Autor*innen der Med Uni Graz: Reibnegger Gilbert
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Abstract:: Recent evidence suggests that immune responses in vivo as well as in vitro are accompanied by release of neopterin [C. H. Huber, et al. (1983) J. Immunol. 130, 1047]. This investigation aimed to elucidate the genetic control of in vitro neopterin release in family mixed lymphocyte culture (MLC) studies. Neopterin levels and responder cell proliferation were assessed in a total of 92 MLCs established from different intrafamilial combinations. Results indicated a strong association between the magnitude of responder cell proliferation and the neopterin levels induced by stimulation with allogeneic cells. This conclusion was based on three findings: first, almost no neopterin release and proliferation was seen in MLCs established between HLA genotypically identical siblings; secondly, very low proliferation and neopterin levels were observed in MLCs between HLA-DR phenotypically identical family members; and thirdly, high neopterin release and strong cellular proliferation were a feature of MLCs established between individuals differing for at least one HLA-DR antigen. We thus conclude that T cell activation subsequent to recognition of HLA-DR disparity represents an essential prerequisite for induction of neopterin release in human MLC.
Find related publications in this database (using NLM MeSH Indexing): Biopterin - analogs and derivatives; Female - analogs and derivatives; HLA-DR Antigens - analogs and derivatives; Histocompatibility Antigens Class II - genetics; Humans - genetics; Lymphocyte Activation - genetics; Lymphocyte Culture Test, Mixed - genetics; Lymphocytes - immunology; Male - immunology; Neopterin - immunology; Phenotype - immunology; Pteridines - secretion; T-Lymphocytes, Helper-Inducer - immunology