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Sommer, NG; Weinberg, AM.
Magnesium's role in bone fractures of overweight children and adolescents
J MINERAL MUSKULOSK. 2021; 28(2): 39-46. Doi: 10.1007/s41970-021-00151-z
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Leading authors Med Uni Graz: Sommer Nicole
Co-authors Med Uni Graz: Weinberg Annelie-Martina
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Abstract:: The incidence of obesity is dramatically increasing, especially among children and adolescents. Obesity is the first step towards metabolic syndrome. In adults, metabolic syndrome has been associated with hypomagnesemia. Only recently, magnesium (Mg2+) deficiency and the prominent actors of metabolic syndrome, including insulin resistance, hyperglycemia, and inflammation, have been associated with increased risk of bone fractures in adults. Especially during growth, nutrition plays a key role. Regarding skeletal maturation, Mg2+ is an essential key player in children and adolescents. Hypomagnesemia inevitably leads to reduced bonemass, brittle bone, and increased risk for fractures. However, different studies suggested an increased risk for bone fractures in obese children and adolescents. This result remains controversial: on the one hand, the low number of patients in pediatric clinical trials must be criticized; on the other hand, it still remains unclear whether less body stabilization and coordination due to lower physical activity plays a key role in the increased frequency of bone fractures in overweight and/or obese children and adolescents. Whether hypomagnesemia affects bone structure and plays a key role in osteoimmunology in children and adolescents needs further elucidation. In addition, hypomagnesemia also affects systemic immunity in later stages of life in adults; hence, changes in children and adolescents need to be assessed.
Find related publications in this database (Keywords): Hypomagnesemia; Pediatric orthopedics; Obesity; Pediatric traumatology; Bone fragility